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Aberrant resting\u2010state functional connectivity (rsFC) of the amygdala and hippocampus are implicated in PTSD and verbal memory impairment. We tested rsFC between bilateral dentate gyrus (DG) and both centromedial (CM) and basolateral (BL) nuclei of the amygdala as statistical mediators for the effect of sexual trauma\u2013related symptom severity on delayed verbal recall performance in 63 older women (age: 60\u201085 years) undiagnosed with PTSD. Participant data were drawn from the NKI\u2010Rockland Study. Individuals completed a 10\u2010min resting\u2010state scan, Rey Auditory Verbal Learning Test (RAVLT), and the Sexual Abuse Trauma Index (SATI) from the Trauma Symptom Checklist. <jats:italic>Z<\/jats:italic>\u2010scores indicating rsFC of DG with BL and CM amygdala seeds were evaluated in two separate mediation models. Higher SATI scores were associated with lower RAVLT after controlling for age, \u03b2\u00a0=\u00a0\u2212.23, 95% CI\u2009[.48, .03], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.039. This effect was negated upon adding a negative path from SATI to rsFC of left DG and right CM, \u03b2\u00a0=\u00a0\u2212.29, 95% CI\u2009[\u2212.52, \u2010.02], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.022, and a positive path from that seed pair to RAVLT List A recall, \u03b2\u00a0=\u00a0.28, 95% CI\u2009[.03, 0.48], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.015. Chi\u2010square fit indices supported partial mediation by this seed pair, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.762. In the absence of PTSD sexual trauma symptoms partially relate to verbal learning deficits as a function of aberrant rsFC between left hippocampus DG and right amygdala CM nuclei.<\/jats:p>","DOI":"10.1002\/jts.22778","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T03:32:51Z","timestamp":1644809571000},"page":"631-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Learning to forget: Hippocampal\u2013amygdala connectivity partially mediates the effect of sexual trauma severity on verbal recall in older women undiagnosed with posttraumatic stress disorder"],"prefix":"10.1002","volume":"35","author":[{"given":"Roger","family":"McIntosh","sequence":"first","affiliation":[{"name":"Department of Psychology University of Miami  Coral Gables Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith D.","family":"Lobo","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Miami  Coral Gables Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Miami  Coral Gables Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Ironson","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Miami  Coral Gables Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103940(99)00488\u20107"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.10.1482"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197\u20104580(01)00278\u20100"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010005\u20100025\u20105"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00830.2009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.10.038"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20648"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1300\/J155v07n01_01"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0886260510372946"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22263"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010008\u20109054\u2010z"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u20102909.107.2.238"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008\u20103836"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"issue":"3","key":"e_1_2_6_16_1","first-page":"187","article-title":"Alterations in default network connectivity in posttraumatic stress disorder related to early\u2010life trauma","volume":"34","author":"Bluhm R. 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