{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T05:47:21Z","timestamp":1778996841903,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T00:00:00Z","timestamp":1670112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Traumatic Stress"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Posttraumatic stress disorder (PTSD) affects 1 in 20 reproductive\u2010aged women and is associated with cardiovascular disease morbidity and mortality. The pathophysiology linking PTSD to cardiovascular disease in nonpregnant adults is proposed to include hypothalamic and autonomic dysregulation; however, the pathways explaining this association in pregnancy are unclear. We examined diurnal cortisol and ambulatory blood pressure (BP) among 254 pregnant women at approximately 12 and 32 gestational weeks. Participants were, on average, 31 years old (<jats:italic>SD<\/jats:italic> = 5), 24.4% reported their ethnicity as Hispanic, and 62.2% reported their race as White. PTSD symptoms were measured using the PTSD Checklist for <jats:italic>DSM\u20105<\/jats:italic> (PCL\u20105). Hierarchical linear regression analyses were performed to examine associations pregnancy between PTSD and cortisol at awakening, 30 min after awakening, and bedtime in early and late pregnancy, as well as associations between PTSD symptoms and daytime and nighttime systolic (SBP) and diastolic BP (DBP) and BP variability. Logistic regression analyses were conducted to test associations between PTSD symptoms and BP dipping. The results showed a positive association between PTSD symptoms and nighttime BP and BP variability at 32 gestational weeks, \u2206<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = .036\u2013.067. PTSD symptoms were negatively associated with awakening cortisol at 12 gestational weeks in unadjusted models. These findings contribute to understanding the associations between PTSD and adverse cardiovascular conditions in pregnancy. More research is needed to replicate these findings and examine whether PTSD interventions are effective at modifying pathways and decreasing the risk for cardiovascular complications in pregnancy.<\/jats:p>","DOI":"10.1002\/jts.22895","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T07:30:49Z","timestamp":1670225449000},"page":"239-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Posttraumatic stress disorder, diurnal cortisol, and ambulatory blood pressure in early and late pregnancy"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-7846","authenticated-orcid":false,"given":"Margaret H.","family":"Bublitz","sequence":"first","affiliation":[{"name":"Department of Medicine Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Department of Psychiatry and Human Behavior Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Women's Medicine Collaborative The Miriam Hospital  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Nillni","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Women's Health Sciences Division, National Center for PTSD VA Boston Healthcare System  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8756-5618","authenticated-orcid":false,"given":"Nicole R.","family":"Nugent","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Department of Pediatrics Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Department of Emergency Medicine Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Sanapo","sequence":"additional","affiliation":[{"name":"Department of Medicine Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Women's Medicine Collaborative The Miriam Hospital  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naya","family":"Habr","sequence":"additional","affiliation":[{"name":"Women's Medicine Collaborative The Miriam Hospital  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada","family":"Bourjeily","sequence":"additional","affiliation":[{"name":"Department of Medicine Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Women's Medicine Collaborative The Miriam Hospital  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2020.1833644"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. (2013).Diagnostic and statistical manual of mental disorders(5th ed.).","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/joe\u201016\u20100340"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/pas0000254"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2018.01.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2021.102923"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291716003378"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.06.031"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101681.1998.tb02301.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.617"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.06.008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525\u20101497.2001.016009606.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2014.04.027"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737\u2010014\u20100467\u2010y"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12546"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2016.156"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.114.03694"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2016.04.008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2020.1863578"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsab281"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/837596"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573402114666180924143801"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogn.2017.10.008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmwh.2005.04.024"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12349"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.114.014492"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010021\u201003599\u20107"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.04.023"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.05.017"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2020.06.006"},{"key":"e_1_2_7_32_1","unstructured":"Weathers F. W. Litz B. T. Keane T. M. Palmieri P. A. Marx B. P. &Schnurr P. P.(2013).The PTSD Checklist for DSM\u20105 (PCL\u20105).https:\/\/www.ptsd.va.gov\/professional\/assessment\/adult\u2010sr\/ptsd\u2010checklist.asp"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005\u20100550"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0b013e32835f4fc7"}],"container-title":["Journal of Traumatic Stress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jts.22895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jts.22895","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jts.22895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:48:23Z","timestamp":1692686903000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jts.22895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,4]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/jts.22895"],"URL":"https:\/\/doi.org\/10.1002\/jts.22895","archive":["Portico"],"relation":{},"ISSN":["0894-9867","1573-6598"],"issn-type":[{"value":"0894-9867","type":"print"},{"value":"1573-6598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,4]]},"assertion":[{"value":"2022-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}