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The availability of multiple evidence\u2010based treatment options creates a need to determine predictors of outcome to enable clinicians to make informed treatment recommendations. We examined perceived social support as a predictor of treatment adherence and response among 196 adults with PTSD enrolled in a multicenter pragmatic randomized controlled noninferiority trial. Perceived social support was measured using the\u00a0Multidimensional Scale of Perceived Social Support and PTSD was assessed using the Clinician\u2010Administered PTSD Scale for <jats:italic>DSM\u20105<\/jats:italic>. Linear regression was used to explore the associations between different dimensions of perceived social support (i.e., from friends, family, and significant others) and posttraumatic stress symptoms (PTSS) at baseline. Linear and logistic regression were used to determine whether these dimensions of support predicted treatment adherence or response for either treatment modality. Lower baseline perceived social support from family was associated with higher levels of PTSS, <jats:italic>B<\/jats:italic> = \u22120.24, 95% CI [\u22120.39, \u22120.08], <jats:italic>p<\/jats:italic> = .003, but the same did not apply to social support from friends or significant others. We did not find evidence that any dimension of social support predicted treatment adherence or response for either treatment. This work does not indicate that social support is a factor that can help predict the suitability of psychological therapy for PTSD delivered via guided internet\u2010based self\u2010help versus face\u2010to\u2010face.<\/jats:p>","DOI":"10.1002\/jts.22947","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T07:57:42Z","timestamp":1686124662000},"page":"511-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Social support as a predictor of outcomes of cognitive behavioral therapy with a trauma focus delivered face\u2010to\u2010face and via guided internet\u2010based self\u2010help"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-9377","authenticated-orcid":false,"given":"Catrin","family":"Lewis","sequence":"first","affiliation":[{"name":"National Centre for Mental Health Division of Psychological Medicine and Clinical Neurosciences Cardiff 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University Health Board  Cardiff United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil P.","family":"Roberts","sequence":"additional","affiliation":[{"name":"National Centre for Mental Health Division of Psychological Medicine and Clinical Neurosciences Cardiff University School of Medicine Cardiff University  Cardiff United Kingdom"},{"name":"Psychology and Psychological Therapies Directorate Cardiff and Vale University Health Board  Cardiff United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Simon","sequence":"additional","affiliation":[{"name":"National Centre for Mental Health Division of Psychological Medicine and Clinical Neurosciences Cardiff University School of Medicine Cardiff University  Cardiff United Kingdom"},{"name":"Psychology and Psychological Therapies Directorate Cardiff and Vale University Health Board  Cardiff United 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