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Previous work has often isolated a single risk factor or a small number of risk factors, making it is difficult to know which may be the most important to study or target in interventions. We used a supervised machine learning technique,\n                    <jats:italic>elastic net<\/jats:italic>\n                    , to test the associations between posttraumatic stress symptoms (PTSS) and several self\u2010reported risk factors at the full\u2010scale, subscale, and item levels in a large online sample (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a01,186) of individuals who endorsed experiencing a\n                    <jats:italic>DSM\u20105<\/jats:italic>\n                    Criterion A traumatic event, allowing for a broader and more granular understanding of the associations between transdiagnostic risk factors and PTSS. In our full\u2010scale model, posttraumatic cognitions, \u03b2\u00a0=\u00a0.28; anxiety sensitivity, \u03b2\u00a0=\u00a0.21; and posttraumatic maladaptive beliefs, \u03b2\u00a0=\u00a0.18, explained the largest amount of variance in PTSS. At the subscale level, heightened threat perceptions of harm, \u03b2\u00a0=\u00a0.30; negative cognitions about the self, \u03b2\u00a0=\u00a0.23; and cognitive sensitivity, \u03b2\u00a0=\u00a0.14, explained the largest amount of variance in PTSS. Meanwhile, at the item level, not feeling safe, not knowing oneself, and self\u2010blame for a traumatic event had the highest importance ratings. The identified variables may be important targets in future longitudinal and treatment research.\n                  <\/jats:p>","DOI":"10.1002\/jts.70020","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T12:48:17Z","timestamp":1762778897000},"page":"86-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disorder\u2010specific and transdiagnostic vulnerability to posttraumatic stress symptoms: A machine learning approach"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7984-8466","authenticated-orcid":false,"given":"Robert E.","family":"Fite","sequence":"first","affiliation":[{"name":"Department of Psychological and Brain Sciences Indiana University\u2013Bloomington  Bloomington Indiana 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