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The efficacy of these interventions among sexual\u2010 and\/or gender\u2010minoritized (SGM) individuals has not been thoroughly investigated within randomized clinical trials (RCTs), despite known elevations in exposure to potentially traumatic events and PTSD symptoms relative to cisgender heterosexual individuals. We conducted a systematic literature review to examine the frequency with which SGM adults were enrolled in RCTs of CPT, PE, and EMDR and investigate these interventions\u2019 efficacy in reducing PTSD symptoms among SGM adults. We searched eight databases to identify RCTs published before August 7, 2025. The inclusion criteria were: written in English; RCT investigating the impact of CPT, PE, or EMDR on PTSD symptoms; utilized a standardized PTSD measure; reported PTSD outcome data; and enrolled individuals who were at least 18 years old. Literature reviews, case studies, protocols, and non\u2013peer reviewed articles were excluded. Our search returned 1,821 unique records, with 519 meeting all eligibility criteria. Ten records reported sexual orientation and gender identity (SOGI) information and enrolled at least one SGM individual. Among studies that reported SOGI information, 12.1% and 2.2% of participants identified as sexual\u2010 and gender\u2010minoritized, respectively. Results highlight that SOGI information is underreported in PTSD treatment research, posing significant challenges in determining the relative efficacy of these treatments and the extent to which SGM\u2010affirmative adaptations are necessary. We offer recommendations for clinicians and researchers, including consistent reporting of full SOGI data.<\/jats:p>","DOI":"10.1002\/jts.70043","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:51:07Z","timestamp":1768891867000},"page":"716-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inclusion of sexual\u2010 and gender\u2010minoritized individuals in randomized clinical trials of first\u2010line treatments for posttraumatic stress disorder: A systematic literature review"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9949-8385","authenticated-orcid":false,"given":"Marley","family":"Warren","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-7716","authenticated-orcid":false,"given":"Lia J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-8050","authenticated-orcid":false,"given":"Sarah A.","family":"Pridgen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3974-1802","authenticated-orcid":false,"given":"Philip","family":"Held","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"*Included in the review."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-54509-7_1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. 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