{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:58:22Z","timestamp":1781330302510,"version":"3.54.1"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Traumatic Stress"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this commentary on Morland et\u00a0al. (2026)\u2019s recent State of the Science article on 3,4\u2010methylenedioxymethamphetamine (MDMA)\u2013assisted psychotherapy for posttraumatic stress disorder (PTSD), we aim to emphasize both MDMA's therapeutic promise and its unresolved scientific challenges. Although recent trials on MDMA\u2010assisted interventions have reported encouraging reductions in PTSD symptoms, the current evidence base remains constrained by several major limitations, including difficulties in blinding, expectancy effects, the absence of robust active comparator conditions, limited mechanistic clarity, and concerns regarding safety monitoring and sample generalizability. This letter argues that these issues are not peripheral but central to the interpretation and future translation of MDMA\u2010assisted psychotherapy. It further highlights the need to move beyond symptom reduction as the primary outcome and incorporate broader indicators of recovery, such as functioning, quality of life, relational restoration, and long\u2010term durability of treatment gains. In addition, we call for stronger attention to equity, scalability, therapist training, and ethical safeguards, particularly if MDMA\u2010assisted psychotherapy is to be considered within a global mental health framework. The discussion aims to stimulate deeper debate on how innovation in trauma treatment should be evaluated before widespread clinical adoption.<\/jats:p>","DOI":"10.1002\/jts.70094","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T14:40:03Z","timestamp":1779633603000},"page":"601-603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From therapeutic promise to evidentiary discipline: Reassessing MDMA\u2010assisted psychotherapy for posttraumatic stress disorder"],"prefix":"10.1002","volume":"39","author":[{"given":"Kadek","family":"Suhardita","sequence":"first","affiliation":[{"name":"Department of Guidance and Counseling Universitas PGRI Mahadewa Indonesia  Denpasar Bali Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veno Dwi","family":"Krisnanda","sequence":"additional","affiliation":[{"name":"Department of Guidance and Counseling Universitas Indraprasta PGRI  South Jakarta Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikas","family":"Saputra","sequence":"additional","affiliation":[{"name":"Department of Guidance and Counseling Universitas Islam Negeri Raden Fatah Palembang  Palembang City South Sumatra Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andika Ari","family":"Saputra","sequence":"additional","affiliation":[{"name":"Department of Guidance and Counseling Universitas Ma'arif Lampung  Metro City Lampung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agung Slamet","family":"Kusmanto","sequence":"additional","affiliation":[{"name":"Department of Guidance and Counseling Universitas Muria Kudus  Central Java Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.3.022806.091432"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1163\/15700682\u201012341372"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051\u20106673\u20101\u20109"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.70061"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008066.2024.2378651"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.70060"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14786"},{"key":"e_1_2_4_9_1","volume-title":"Posttraumatic stress disorder and alcohol use disorder in women","author":"Persson A.","year":"2025"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11263\u2010025\u201002672\u20104"}],"container-title":["Journal of Traumatic Stress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jts.70094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jts.70094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jts.70094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:30:47Z","timestamp":1781328647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jts.70094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,24]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jts.70094"],"URL":"https:\/\/doi.org\/10.1002\/jts.70094","archive":["Portico"],"relation":{},"ISSN":["0894-9867","1573-6598"],"issn-type":[{"value":"0894-9867","type":"print"},{"value":"1573-6598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,24]]},"assertion":[{"value":"2026-05-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}