{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:54:04Z","timestamp":1791266044349,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Traumatic Stress"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The present study utilized posttraumatic stress disorder (PTSD) clinical trials repository data to analyze associations between treatment frequency (i.e., weekly or more than weekly) and completion outcomes across cognitive processing therapy (CPT), prolonged exposure (PE), and eye movement desensitization and reprocessing (EMDR). Covariates included treatment type, interactions between treatment type and treatment frequency, total number of treatment sessions, mean age, and study\u2010level risk of bias. All studies that met the eligibility criteria were included with CPT, PE, and EMDR in a secondary analysis to evaluate patterns in operationalizing treatment completion. A total of 84 study arms (\n                    <jats:italic>k<\/jats:italic>\n                    = 66 studies) were included in the primary analysis. Compared to CPT, patients had slightly lower odds of completing PE, odds ratio (\n                    <jats:italic>OR<\/jats:italic>\n                    ) = 0.73, 95% confidence interval (CI) [0.62, 0.86], but were twice as likely to complete EMDR,\n                    <jats:italic>OR<\/jats:italic>\n                    = 2.44, 95% CI [1.82, 3.27]. Increasing the frequency of PE doubled the odds of completion compared to CPT,\n                    <jats:italic>OR<\/jats:italic>\n                    = 2.15, 95% CI [1.55, 2.99]. A Frequency \u00d7 Treatment interaction signal was nonsignificant for EMDR,\n                    <jats:italic>OR<\/jats:italic>\n                    = 1.61, 95% CI [0.96, 2.71]. Secondary outcomes revealed substantial heterogeneity in definitions of treatment completion, with only one third of all CPT, PE, and EMDR trial arms explicitly defining treatment completion as completing all treatment sessions. Future research should expand these findings to other modalities, as well as standardize operationalizations of treatment completion.\n                  <\/jats:p>","DOI":"10.1002\/jts.70111","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:51:19Z","timestamp":1785131479000},"page":"775-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pacing in posttraumatic stress disorder therapy: A meta\u2010regression of treatment frequency and completion rates"],"prefix":"10.1002","volume":"39","author":[{"given":"David M.","family":"Horton","sequence":"first","affiliation":[{"name":"Department of Learning Health Sciences University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Learning Health Sciences University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Michigan School of Nursing  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P.","family":"Grau","sequence":"additional","affiliation":[{"name":"Health Services Research and Development Veterans Affairs Center for Clinical Management Research  Ann Arbor Michigan USA"},{"name":"Department of Psychiatry University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy M.","family":"Kilbourne","sequence":"additional","affiliation":[{"name":"Department of Learning Health Sciences University of Michigan Medical School  Ann Arbor Michigan USA"},{"name":"Office of Research and Development Veterans Health Administration, U.S. Department of Veterans Affairs  Washington, DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/16506073.2018.1522371"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2015.05.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291722000927"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13040552"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21242"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/med-psych\/9780190926939.001.0001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2025.10.004"},{"key":"e_1_2_9_9_1","unstructured":"International Society for Traumatic Stress Studies. (2019).Posttraumatic stress disorder prevention and treatment guidelines: Methodology and recommendations.https:\/\/istss.org\/wp\u2010content\/uploads\/2024\/08\/ISTSS_PreventionTreatmentGuidelines_FNL\u2010March\u201019\u20102019.pdf"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2022.104123"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2017.10.009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2026.102720"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22822"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2019.1709709"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.12703\/P7\u201043"},{"key":"e_1_2_9_16_1","unstructured":"National Center for PTSD. (n.d.).PTSD Repository: Clinical trials database.https:\/\/www.ptsd.va.gov\/ptsdrepository\/index.asp"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22520"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","unstructured":"Penix\u2010Smith E. A. &Swift J. K.(2025).The protocol matters: A meta\u2010analysis of psychotherapy dropout from specific PTSD treatment approaches in U.S. service members and veterans.Psychological Trauma: Theory Research Practice and Policy. Advance online publication.https:\/\/doi.org\/10.1037\/tra0002070","DOI":"10.1037\/tra0002070"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.49422"},{"key":"e_1_2_9_20_1","volume-title":"Cognitive processing therapy for PTSD: A comprehensive therapist manual","author":"Resick P. A.","year":"2024"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.36921"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22556"},{"key":"e_1_2_9_23_1","volume-title":"Eye movement desensitization and reprocessing (EMDR) therapy: Basic principles, protocols, and procedures","author":"Shapiro F.","year":"2018"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/ser0000833"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2021.1947570"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0037512"},{"key":"e_1_2_9_27_1","unstructured":"U.S. Department of Veterans Affairs\/U.S. Department of Defense. (2023).VA\/DoD clinical practice guideline for management of posttraumatic stress disorder and acute stress disorder.https:\/\/www.healthquality.va.gov\/guidelines\/MH\/ptsd\/VA\u2010DoD\u2010CPG\u2010PTSD\u2010Full\u2010CPGAug242023.pdf\u2216"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadr.2021.100093"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpra.2022.05.004"}],"container-title":["Journal of Traumatic Stress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jts.70111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jts.70111","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jts.70111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:17:14Z","timestamp":1791263834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jts.70111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,26]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jts.70111"],"URL":"https:\/\/doi.org\/10.1002\/jts.70111","archive":["Portico"],"relation":{},"ISSN":["0894-9867","1573-6598"],"issn-type":[{"value":"0894-9867","type":"print"},{"value":"1573-6598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,26]]},"assertion":[{"value":"2026-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}