{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:16:02Z","timestamp":1788509762755,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Traumatic Stress"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Posttraumatic stress disorder (PTSD) disrupts individual well\u2010being and relationship health, particularly among veteran\/military couples with heightened risks due to deployment, family reintegration, and traumatic stress. Although cognitive\u2010behavioral conjoint therapy (CBCT) and brief CBCT (bCBCT) have demonstrated strong efficacy in reducing PTSD symptoms, their impact on relational outcomes is less compelling. Given the importance of relationship functioning for veterans\u2019 overall health, enhancing interpersonal outcomes of PTSD treatment remains a research priority. One promising approach is the integration of 3,4\u2010methylenedioxymethamphetamine (MDMA)\u2013assisted therapy to augment the relational benefits of established PTSD interventions. This single\u2010site, open\u2010label pilot study evaluated the preliminary benefit, safety, and acceptability of MDMA\u2010assisted bCBCT in eight U.S. military veterans with PTSD and their intimate partners (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a016). An eight\u2010session MDMA\u2010assisted bCBCT protocol with two MDMA administration sessions and dyadic integration sessions incorporating elements of integrative behavioral couples therapy was delivered. Outcomes included PTSD symptom severity, relationship functioning, and safety. Veterans exhibited large pre\u2013post PTSD symptom reductions,\n                    <jats:italic>d<\/jats:italic>\n                    \u00a0=\u00a01.25, which were generally maintained during follow\u2010up. Both veterans and partners experienced large improvements in relationship functioning,\n                    <jats:italic>d<\/jats:italic>\n                    s\u00a0=\u00a01.83 and 1.29, respectively, with moderate rebound during follow\u2010up. No serious adverse events were reported. This first trial of MDMA\u2010assisted bCBCT in U.S. veterans and their partners provides preliminary evidence of potential improvements in PTSD and relational outcomes, with no identified serious safety concerns. This model has potential for future evaluation in large health care systems, leveraging the hypothesized therapeutic effects of MDMA for individuals with PTSD and their families.\n                  <\/jats:p>","DOI":"10.1002\/jts.70126","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:50:33Z","timestamp":1788508233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Healing together: Results from a pilot trial of 3,4\u2010Methylenedioxymethamphetamine\u2010enhanced cognitive\u2010behavioral conjoint therapy for posttraumatic stress disorder"],"prefix":"10.1002","author":[{"given":"Leslie A.","family":"Morland","sequence":"first","affiliation":[{"name":"Department of Veterans Affairs National Center for PTSD Women's Health Sciences Division  Boston Massachusetts USA"},{"name":"Veterans Affairs San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra E.","family":"Khalifian","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Perivoliotis","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettye","family":"Chargin","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al","family":"Alam","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara R.","family":"Wachsman","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System  San Diego California USA"},{"name":"San Diego State University\/University of California San Diego Joint Doctoral Program in Clinical Psychology  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhakshin","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Bismark","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Stauffer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Oregon Health and Science University  Portland Oregon USA"},{"name":"Veterans Affairs Portland Health Care System  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Remedy  Toronto Canada"},{"name":"Department of Psychology Toronto Metropolitan University  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail C.","family":"Angkaw","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla C.","family":"Knopp","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. 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