{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:51:55Z","timestamp":1791276715389,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009711","name":"EMDR Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Traumatic Stress"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Depressive symptoms are\u00a0frequently\u00a0comorbid with posttraumatic stress disorder (PTSD), yet it\u00a0remains\u00a0unclear whether depressive symptom severity before the start of treatment affects the results of trauma\u2010focused psychotherapy. We hypothesized that baseline depressive symptom severity might reduce overall PTSD symptom improvement and could differentially affect treatment response to imagery rescripting (ImRs) versus eye movement desensitization and reprocessing (EMDR). This secondary analysis of a randomized controlled trial included 150 adults with childhood trauma\u2013related PTSD. Participants received 12 sessions of EMDR or ImRs. Baseline depressive symptoms were assessed using the Beck Depression Inventory\u2013II (BDI\u2010II), and PTSD severity was assessed using the Clinician\u2010Administered PTSD Scale for\n                    <jats:italic>DSM\u20105<\/jats:italic>\n                    (CAPS\u20105). Mixed\u2010effects models were used to examine (a) the effect of baseline depressive symptom severity on PTSD outcomes and (b) its interaction with treatment condition over time. Baseline depressive symptom severity did not significantly predict PTSD outcomes,\n                    <jats:italic>RR<\/jats:italic>\n                    \u00a0=\u00a01.005,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.460, and did not moderate the relative effectiveness of EMDR and ImRs,\n                    <jats:italic>RRs<\/jats:italic>\n                    \u00a0=\u00a00.986\u20130.999,\n                    <jats:italic>p<\/jats:italic>\n                    s\u00a0&gt;\u00a0.202. Both interventions were effective regardless of baseline depression, contrary to our hypotheses, though the findings may be limited by the use of a self\u2010report depressive symptom measure, which may not capture broader clinical features of depression, and a sample limited to adults with childhood trauma\u2010related PTSD. Overall, these findings support trauma\u2010focused treatments irrespective of comorbid depressive symptom severity.\n                  <\/jats:p>","DOI":"10.1002\/jts.70129","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:08:28Z","timestamp":1791274108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Depressive symptom severity and treatment outcome in posttraumatic stress disorder following childhood trauma: A secondary analysis of a randomized clinical trial"],"prefix":"10.1002","author":[{"given":"Lisanne M.","family":"Koomen","sequence":"first","affiliation":[{"name":"Parnassia Psychiatric Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathijs L.","family":"Deen","sequence":"additional","affiliation":[{"name":"Parnassia Group  The Hague The Netherlands"},{"name":"Methodology and Statistics Department, Institute of Psychology Leiden University  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie A.","family":"Rameckers","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology University of Amsterdam  Amsterdam The Netherlands"},{"name":"Academic Center for Trauma and Personality  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences The University of Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Fassbinder","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Christian\u2010Albrechts\u2010Universit\u00e4t zu Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen M.","family":"Rijkeboer","sequence":"additional","affiliation":[{"name":"Faculty of Psychology and Neuroscience, Department of Clinical Psychological Science Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina L. Boterhoven de","family":"Haan","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnoud","family":"Arntz","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology University of Amsterdam  Amsterdam The Netherlands"},{"name":"Academic Center for Trauma and Personality  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"American Psychiatric Association. (2000).Diagnostic and statistical manual of mental disorders(4th ed. text rev.)."},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. 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