{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:46:56Z","timestamp":1767340016292},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:00:00Z","timestamp":1495584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Preoperative localization of parathyroid adenomas in patients with primary hyperparathyroidism facilitates targeted surgery. We assessed the sensitivity of 3\u2010dimensional (3D) sonography for preoperative localization of abnormal parathyroid glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective review of patients who underwent parathyroidectomy for primary hyperparathyroidism at a single site at our institution. We compared preoperative 2\u2010dimensional (2D) sonography, 3D sonography, and sestamibi scans with final gland localization at surgery. Two readers reviewed the sonograms to assess inter\u2010reader variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From January 2010 through April 2015, 52 patients underwent parathyroidectomy after preoperative 2D sonography, 3D sonography, and sestamibi scans. Three\u2010dimensional sonography had sensitivity of 88\u201392% compared with 69\u201371% for 2D sonography for gland localization. In patients in whom sonography and sestamibi scans localized abnormalities to the same side, the sensitivities were 100% (43 of 43) for 3D sonography and 96% (48 of 50) for 2D sonography. Three\u2010dimensional sonography had significantly higher sensitivity for localization of glands smaller than 500\u2009mg compared with 2D sonography (88% versus 58%; <jats:italic>P<\/jats:italic>\u2009=\u2009.012). There was better inter\u2010reader agreement between the radiologists when using 3D sonography (\u03ba\u2009=\u20090.65) compared with 2D sonography (\u03ba\u2009=\u20090.41).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found a significantly higher sensitivity and better inter\u2010reader agreement for 3D sonography compared with 2D sonography for preoperative identification of abnormal parathyroid glands, especially among smaller glands.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14245","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T16:26:14Z","timestamp":1495729574000},"page":"1897-1904","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sensitivity of 3\u2010Dimensional Sonography in Preoperative Evaluation of Parathyroid Glands in Patients With Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"36","author":[{"given":"Susan 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