{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:26:50Z","timestamp":1777588010603,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to evaluate the global sphericity index (GSI) of the 4\u2010chamber view and correlate the results with abnormal ultrasound findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The epicardial end\u2010diastolic basal\u2010apical length (BAL) and transverse length (TL) of the 4\u2010chamber view were measured to compute the GSI (BAL\/TL) in 200 control fetuses between 20 and 40 weeks' gestation. Three hundred study fetuses were prospectively examined between 17 and 39 weeks' gestation. The GSI, <jats:italic>Z<\/jats:italic> score, and centile were computed for each of the fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The GSI (1.233; SD, 0.0953) in the control fetuses was independent of gestational age. Eighteen percent of the study fetuses (55 of 300) had a GSI below the 5th centile (&lt;1.08), of whom 96% (53 of 55) had additional abnormal ultrasound findings. Fetuses with an estimated fetal weight below the 10th centile had a significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) higher rate of an umbilical artery Doppler pulsatility index above the 95th centile (27% versus 17.7%), a middle cerebral artery Doppler pulsatility index below the 5th centile (27% versus 0%), an abnormal cerebroplacental ratio (27% versus 4.5%), and an amniotic fluid index of less than 5\u2009cm (36% versus 9%). The TL was significantly increased compared with the BAL in fetuses with cardiac dysfunction, irrespective of the estimated fetal weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An abnormal GSI below the 5th centile is associated with abnormal fetal ultrasound findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14261","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T13:41:58Z","timestamp":1496151718000},"page":"2309-2318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Abnormal Fetal Findings Associated With a Global Sphericity Index of the 4\u2010Chamber View Below the 5th Centile"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-572X","authenticated-orcid":false,"given":"Greggory R.","family":"DeVore","sequence":"first","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of 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