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Contrast\u2010enhanced ultrasound (US) imaging is a novel imaging technique in which intravenously injected gas\u2010filled microbubbles generate enhanced US echoes from an acoustic impedance mismatch. This article describes contrast\u2010enhanced US imaging in 2 neonates with hypoxic ischemic injury and future directions on developing quantitative contrast\u2010enhanced US techniques for improved characterization of perfusion abnormalities. The importance of studying the temporal evolution of brain perfusion in neonatal hypoxic ischemic injury is also highlighted.<\/jats:p>","DOI":"10.1002\/jum.14289","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T07:06:37Z","timestamp":1498460797000},"page":"2379-2386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Novel Contrast\u2010Enhanced Ultrasound Evaluation in Neonatal Hypoxic Ischemic Injury: Clinical Application and Future Directions"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0125-2686","authenticated-orcid":false,"given":"Misun","family":"Hwang","sequence":"first","affiliation":[{"name":"Division of Pediatric Radiology Russell H. 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