{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:55:21Z","timestamp":1740171321445,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:00:00Z","timestamp":1500249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministry of Economy and Competitiveness","doi-asserted-by":"publisher","award":["grant MTM2012\u201038067\u2010C02\u201001"],"award-info":[{"award-number":["grant MTM2012\u201038067\u2010C02\u201001"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["grant 2014 SGR 464"],"award-info":[{"award-number":["grant 2014 SGR 464"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Liver fibrosis (LF) is crucial for the individualized management of patients with hepatitis C virus (HCV). We evaluated the concordance between two noninvasive methods for staging LF, transient elastography (TE) and acoustic radiation force impulse (ARFI), in patients coinfected with human immunodeficiency virus and HCV. We propose an algorithm for optimal use of both techniques in routine clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 89 human immunodeficiency virus\/HCV\u2010coinfected patients underwent TE and ARFI on the same day. The kappa index was used to assess concordance between the techniques. An algorithm combining ARFI and TE was proposed based on the independent factors associated with a kappa index greater than or equal to 0.70, obtained from a multiple regression analysis. We performed a cost\u2010effectiveness analysis. The study was approved by our institutional review board and all patients signed the informed consent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Concordance between TE and ARFI for F2, F3, and F4 was 0.55, 0.59, and 0.69, respectively. Ultrasound normal spleen size (odds ratio [OR], 0.20; 95% confidence interval [CI], 0.05\u20130.91) and high viral load (OR, 0.36; 95% CI, 0.17\u20130.77) reduced the probability of agreement between TE and ARFI, whereas ultrasound normal left liver lobe size (OR, 3.32; 95% CI, 1.21\u20139.10) increased this probability. The algorithm revealed that LF was adequately assessed in 74.16%, with 25.84% of patients misclassified. The incremental cost\u2010effectiveness ratio of TE compared with ARFI to increase concordance by 1% was \u20ac8.86.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Concordance between TE and ARFI was moderate. In the algorithm we proposed, ARFI was cost\u2010effective as a first technique for the staging of LF in the study population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14312","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T14:26:37Z","timestamp":1500301597000},"page":"113-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Optimal Use of Transient Elastography and Acoustic Radiation Force Impulse to Stage Liver Fibrosis in HIV\/HCV\u2010Coinfected Patients in Clinical Practice"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1226-2353","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"L\u00f3pez","sequence":"first","affiliation":[{"name":"Internal Medicine Department University Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00faria","family":"P\u00e9rez\u2010\u00c0lvarez","sequence":"additional","affiliation":[{"name":"Departament d'Estad\u00edstica i Investigaci\u00f3 Operativa Universitat Polit\u00e8cnica de Catalunya Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul V.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Radiology Service University Hospital Germans Trias i Pujol Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Jou","sequence":"additional","affiliation":[{"name":"Internal Medicine Department University Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Carbonell","sequence":"additional","affiliation":[{"name":"Internal Medicine Department University Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Radiology Service University Hospital Germans Trias i Pujol Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Soldevila","sequence":"additional","affiliation":[{"name":"Internal Medicine Department University Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Tenesa","sequence":"additional","affiliation":[{"name":"Internal Medicine Department University Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Tor","sequence":"additional","affiliation":[{"name":"Internal Medicine Department University Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonaventura","family":"Clotet","sequence":"additional","affiliation":[{"name":"Internal Medicine Department University Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Departament d'Estad\u00edstica i Investigaci\u00f3 Operativa Universitat Polit\u00e8cnica de Catalunya Barcelona Spain"},{"name":"Irsicaixa Laboratory University Hospital Germans Trias i Pujol Barcelona Spain"},{"name":"Universitat de Vic Vic Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Bechini","sequence":"additional","affiliation":[{"name":"Radiology Service University Hospital Germans Trias i Pujol Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Tural","sequence":"additional","affiliation":[{"name":"Internal Medicine Department University Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Fundaci\u00f3 de la LLuita contra la Sida HIV Clinical Unit, University Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Universitat de Vic Vic Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.11.019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23425"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2007.10.009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2523081928"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.341"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328339e0a1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.03.016"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12240"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-405"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.7844"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2011.0322"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803263381301"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14844-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040842"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-10-200711200-00003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1001\/jama.2012.144878","article-title":"Association between sustained virological response and all\u2010cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis","volume":"308","author":"Van der M","year":"2012","journal-title":"JAMA"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis500"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23020"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.025"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.10.027"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.07.005"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.01.051"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32836381f3"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1086\/313816","article-title":"Prevalence and clinical significance of splenomegaly in asymptomatic human immunodeficiency virus type 1\u2010infected adults. Swiss HIV cohort study","volume":"30","author":"Furrer H","year":"2000","journal-title":"Clin Infect Dis"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2002.21.9.1023"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjum.14312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.14312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:11:40Z","timestamp":1696032700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.14312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,17]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/jum.14312"],"URL":"https:\/\/doi.org\/10.1002\/jum.14312","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"type":"print","value":"0278-4297"},{"type":"electronic","value":"1550-9613"}],"subject":[],"published":{"date-parts":[[2017,7,17]]},"assertion":[{"value":"2016-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}