{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:57:58Z","timestamp":1764133078791,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the diagnostic performance for advanced hepatic fibrosis measured by 2D shear\u2010wave elastography (SWE), using either the coefficient of variance (CV) or the interquartile range divided by the median value (IQR\/M) as quality criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, from January 2011 to December 2013, 96 patients, who underwent both liver stiffness measurement by 2D SWE and liver biopsy for hepatic fibrosis grading, were enrolled. The diagnostic performances of the CV and the IQR\/M were analyzed using receiver operating characteristic curves with areas under the curves (AUCs) and were compared by Fisher's Z test, based on matching the cutoff points in an interactive dot diagram. All <jats:italic>P<\/jats:italic> values less than 0.05 were considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When using the cutoff value IQR\/M of 0.21, the matched cutoff point of CV was 20%. When a cutoff value of CV of 20% was used, the diagnostic performance for advanced hepatic fibrosis (\u2009\u2265\u2009F3 grade) with CV of less than 20% was better than that in the group with CV greater than or equal to 20% (AUC 0.967 versus 0.786, z statistic\u2009=\u20092.23, <jats:italic>P<\/jats:italic>\u2009=\u2009.025), whereas when the matched cutoff value IQR\/M of 0.21 showed no difference (AUC 0.918 versus 0.927, z statistic\u2009=\u2009\u22120.178, <jats:italic>P<\/jats:italic>\u2009=\u2009.859).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The validity of liver stiffness measurements made by 2D SWE for assessing advanced hepatic fibrosis may be judged using CVs, and when the CV is less than 20% it can be considered \u201cmore reliable\u201d than using IQR\/M of less than 0.21.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14341","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T07:10:13Z","timestamp":1502694613000},"page":"355-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Coefficient of Variance as Quality Criterion for Evaluation of Advanced Hepatic Fibrosis Using 2D Shear\u2010Wave Elastography"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1607-3744","authenticated-orcid":false,"given":"Sanghyeok","family":"Lim","sequence":"first","affiliation":[{"name":"Departments of Radiology Hanyang University Guri Hospital, Hanyang University College of Medicine Guri Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Radiology Hanyang University Guri Hospital, Hanyang University College of Medicine Guri Korea"},{"name":"Department of Radiology Suncheon Medical Center Suncheon\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Radiology Hanyang University Guri Hospital, Hanyang University College of Medicine Guri Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Seo","family":"Cho","sequence":"additional","affiliation":[{"name":"Departments of Radiology Hanyang University Guri Hospital, Hanyang University College of Medicine Guri Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Yeob","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Medical Science Hanyang University Guri Hospital, Hanyang University College of Medicine Guri Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-2116","authenticated-orcid":false,"given":"Woo Kyoung","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Radiology and Center for Imaging Science Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Hyun","family":"Sohn","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine Guri Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04861.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.20534"},{"key":"e_1_2_6_4_1","first-page":"129","article-title":"[Clinical application of non\u2010invasive diagnosis for hepatic fibrosis]","volume":"13","author":"Cho SW","year":"2007","journal-title":"Korean J Hepatol"},{"key":"e_1_2_6_5_1","first-page":"155","article-title":"Analysis of histopathological changes that influence liver stiffness in chronic hepatitis C. 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