{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:22:16Z","timestamp":1760955736981,"version":"3.41.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["175022","175087"],"award-info":[{"award-number":["175022","175087"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Structural changes and metabolic stress have been reported on diffusion\u2010weighted magnetic resonance imaging in the cornu ammonis 1 area of the hippocampus in patients with transient global amnesia (TGA), but a consensus on pathogenesis is still lacking. The aim of our study was to perform a comprehensive ultrasound analysis of the cerebrovascular circulation in our population of patients with TGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred patients with TGA and 50 age\u2010 and sex\u2010matched control participants underwent ultrasound examinations of the cervicocranial circulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most significant risk factor for TGA was arterial hypertension (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). There were no significant atherosclerotic lesions on the large arteries of the neck (mean internal carotid artery stenosis\u2009\u00b1\u2009SD, 28.7%\u2009\u00b1\u200911.7%) or on the large intracerebral arteries (good structural and hemodynamic status;<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). Rarely detected microembolic signals or a right\u2010left cardiopulmonary shunt excluded an emboligenic mechanism of TGA (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). The internal jugular vein valves were incompetent in 54% of patients with TGA, and this condition was associated with an increased risk of TGA (odds ratio, 4.16; 95% confidence interval, 1.91\u20139.04). The mean values of the breath holding index and pulsatility index, as parameters of small\u2010vessel function, were within normal ranges and without differences between the TGA and control groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our ultrasound examination did not detect significant structural atherosclerotic changes of cervicocranial arteries, and an emboligenic mechanism was excluded. Only a significant rise of blood pressure in TGA and significant valvular insufficiency of the internal jugular vein were established. New research should clarify whether these simultaneous functional circulatory changes have relevance for metabolic stress in the cornu ammonis of the hippocampus.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14355","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T15:33:33Z","timestamp":1504020813000},"page":"479-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comprehensive Ultrasound Assessment of the Craniocervical Circulation in Transient Global Amnesia"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8809-8617","authenticated-orcid":false,"given":"Zagorka B.","family":"Jovanovic","sequence":"first","affiliation":[{"name":"Neurology Clinic Institute of Cardiology University of Belgrade, Faculty of Medicine, Clinical Center of Serbia Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra M.","family":"Pavlovic","sequence":"additional","affiliation":[{"name":"Neurology Clinic Institute of Cardiology University of Belgrade, Faculty of Medicine, Clinical Center of Serbia Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bosiljka P.","family":"Vujisic Tesic","sequence":"additional","affiliation":[{"name":"Institute of Cardiology University of Belgrade, Faculty of Medicine, Clinical Center of Serbia Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana P.","family":"Pekmezovic","sequence":"additional","affiliation":[{"name":"Neurology Clinic Institute of Cardiology University of Belgrade, Faculty of Medicine, Clinical Center of Serbia Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija V.","family":"Kostic Boricic","sequence":"additional","affiliation":[{"name":"Institute of Cardiology University of Belgrade, Faculty of Medicine, Clinical Center of Serbia Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edita Z.","family":"Cvitan","sequence":"additional","affiliation":[{"name":"Neurology Clinic Institute of Cardiology University of Belgrade, Faculty of Medicine, Clinical Center of Serbia Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadezda M.","family":"Covickovic Sternic","sequence":"additional","affiliation":[{"name":"Neurology Clinic Institute of Cardiology University of Belgrade, Faculty of Medicine, Clinical Center of Serbia Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356431"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70344-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2011.07.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.53.10.834"},{"volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1994","author":"American Psychiatric Association","key":"e_1_2_6_6_1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2292030516"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","unstructured":"TouboulPJ HennericiMG MeairsS et al. 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