{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:30:40Z","timestamp":1759581040946,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC12014229"],"award-info":[{"award-number":["SHDC12014229"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14441900900","15411969000"],"award-info":[{"award-number":["14441900900","15411969000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401417","81501475"],"award-info":[{"award-number":["81401417","81501475"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the diagnostic performance of Virtual Touch tissue imaging quantification (VTIQ; Siemens Medical Solutions, Mountain View, CA) in combination with the Thyroid Imaging Reporting and Data System (TI\u2010RADS) for assessing thyroid nodules referred for biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 197 surgically or cytologically proven thyroid nodules in 187 patients were included. Nodules evaluated by conventional ultrasound (US) and VTIQ examinations were classified into US TI\u2010RADS categories. The shear wave velocity (SWV) on VTIQ was assessed, and the cutoff value was obtained from a receiver operating characteristic curve analysis. Diagnostic performances of conventional US, VTIQ, and their combination were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 134 benign and 63 malignant nodules. The sensitivity and specificity for the US TI\u2010RADS were 98.4% and 20.1%, respectively. The areas under the receiver operating characteristic curves for the mean, maximum, minimum, and ratio of the SWV were 0.818, 0.805, 0.799, and 0.728. With a cutoff value of 2.90\u2009m\/s, the sensitivity and specificity of the mean SWV were 71.4% and 82.8%. By applying this value or less as a standard for downgrading TI\u2010RADS category 4a to category 3 lesions, the specificity significantly rose from 20.1% to 47.0% (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) without a loss of sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The additional application of VTIQ can improve the specificity of the TI\u2010RADS for evaluating thyroid nodules without a loss of sensitivity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14413","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T16:15:01Z","timestamp":1506615301000},"page":"725-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Assessment of Virtual Touch Tissue Imaging Quantification and the Ultrasound Thyroid Imaging Reporting and Data System in Patients With Thyroid Nodules Referred for Biopsy"],"prefix":"10.1002","volume":"37","author":[{"given":"Feng","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute Shanghai China"},{"name":"Thyroid Institute Tongji University School of Medicine Shanghai China"},{"name":"Department of Ultrasound Ningbo First Hospital Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1204-8231","authenticated-orcid":false,"given":"Hui\u2010Xiong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute Shanghai China"},{"name":"Thyroid Institute Tongji University School of Medicine Shanghai China"},{"name":"Shanghai Center for Thyroid Diseases Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute Shanghai China"},{"name":"Thyroid Institute Tongji University School of Medicine Shanghai China"},{"name":"In\u2010Patient Ultrasound Department Second Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Wan","family":"Bo","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute Shanghai China"},{"name":"Thyroid Institute Tongji University School of Medicine Shanghai China"},{"name":"Shanghai Center for Thyroid Diseases Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Long","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute Shanghai China"},{"name":"Thyroid Institute Tongji University School of Medicine Shanghai China"},{"name":"Shanghai Center for Thyroid Diseases Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan\u2010Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute Shanghai China"},{"name":"Thyroid Institute Tongji University School of Medicine Shanghai China"},{"name":"Shanghai Center for Thyroid Diseases Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u2010Ji","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute Shanghai China"},{"name":"Thyroid Institute Tongji University School of Medicine Shanghai China"},{"name":"Shanghai Center for Thyroid Diseases Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute Shanghai China"},{"name":"Thyroid Institute Tongji University School of Medicine Shanghai China"},{"name":"Shanghai Center for Thyroid Diseases Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Mei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute Shanghai China"},{"name":"Thyroid Institute Tongji University School of Medicine Shanghai China"},{"name":"Shanghai Center for Thyroid Diseases Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen","family":"Qu","sequence":"additional","affiliation":[{"name":"Thyroid Institute Tongji University School of Medicine Shanghai China"},{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"},{"name":"Shanghai Center for Thyroid Diseases Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-3-199702010-00009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp031436"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.178.3.1780687"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2373050220"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2473070944"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1724"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0021"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110206"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2015.03.009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0323"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0221-0363(08)70367-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2363041248"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2482071758"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.04.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2751"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042735"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049094"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132438"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.01.021"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-141904"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2015.10.003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2015.06.021"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPHLWMI3JV4LA"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0359-x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0367"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0792-2.50029-8"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.18.2164"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.061730"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0936"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015150056"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2013.07.012"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/960262"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-2847-5"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.02.024"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3455-8"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.33.6.1031"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090674"},{"key":"e_1_2_6_40_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ejrad.2014.11.019","article-title":"Shear wave elastography of thyroid nodules for the prediction of malignancy in a large scale study","volume":"84","author":"Park AY","year":"2014","journal-title":"Eur J Radiol"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1369-7"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjum.14413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.14413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T07:16:01Z","timestamp":1695626161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.14413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,28]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/jum.14413"],"URL":"https:\/\/doi.org\/10.1002\/jum.14413","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"type":"print","value":"0278-4297"},{"type":"electronic","value":"1550-9613"}],"subject":[],"published":{"date-parts":[[2017,9,28]]},"assertion":[{"value":"2017-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}