{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:33Z","timestamp":1786978173961,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T00:00:00Z","timestamp":1506643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Ultrasonography (US) of the median nerve has been increasingly studied and used for confirmation of carpal tunnel syndrome (CTS). However, a consensus on the choice of parameters to be evaluated is still not established. The aim of this diagnostic accuracy study was to assess the diagnostic value of multiple parameters individually, as well as in different combinations of variable complexity, and to find an optimal approach for US\u2010based confirmation of a CTS diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All participants completed clinical and electrophysiologic evaluations, and their hands were scanned with a 5\u201313\u2010MHz linear US transducer. Eighty\u2010six patients with CTS (135 symptomatic hands) and 50 control participants (93 asymptomatic hands) were analyzed. The median nerve was recorded transversely at the forearm, at the carpal tunnel inlet, in the mid tunnel, and at the carpal tunnel outlet. For determining the parameters' diagnostic value, sensitivities, specificities, and area under the curve (AUC) values were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The inlet cross\u2010sectional area, inlet circumference, and outlet cross\u2010sectional area of the median nerve had the highest AUCs (0.962, 0.920, and 0.913, respectively), sensitivities (87.4%, 80.0%, and 74.1%), and specificities (94.6%, 91.4%, and 92.5%) among single\u2010measurement parameters. An analysis of 2\u2010level parameters (wrist\u2010to\u2010forearm\u2010ratio, inlet\u2010to\u2010outlet\u2010ratio, outlet\u2010to\u2010forearm\u2010ratio, and inlet\u2010outlet mean) yielded the highest AUC (0.974) for the mean cross\u2010sectional area of the median nerve [(inlet\u2009+\u2009outlet cross\u2010sectional area)\/2], with high sensitivity (93.5%) and specificity (91.1%). A compound regression\u2010based index yielded a marginally higher AUC (0.989) than the previously mentioned parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results of the study show that the mean cross\u2010sectional area and inlet cross\u2010sectional area may be valid and easy\u2010to\u2010acquire parameters for routine clinical use in confirming CTS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.14417","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T12:48:53Z","timestamp":1506689333000},"page":"879-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Use of Multiple Ultrasonographic Parameters in Confirmation of Carpal Tunnel Syndrome"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-6046","authenticated-orcid":false,"given":"Dra\u017een","family":"A\u017eman","sequence":"first","affiliation":[{"name":"Department of Neurology, Dr J. 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