{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:41:50Z","timestamp":1761986510623,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T00:00:00Z","timestamp":1506643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>There are multiple etiologies for fetal dilated bowel loops on ultrasonography (US), and we present a unique case of male siblings with a forkhead box P3 (<jats:italic>FOXP3<\/jats:italic>) mutation. Both children presented with fetal bowel anomalies on prenatal US. Family histories of cystic fibrosis and immune dysregulation, polyendocrinopathy, enteropathy, X\u2010linked (IPEX) syndrome were reported. Amniocentesis in both pregnancies identified a normal male karyotype and the familial mutation associated with IPEX syndrome. IPEX syndrome is one of a group of conditions known as congenital diarrhea disorders. Other congenital diarrhea disorder cases have presented with similar prenatal US findings. As a result of these associations, we suggest considering IPEX syndrome as a potential cause of fetal bowel anomalies, particularly with a known family history. However, continued research into the phenotypic and genotypic correlations for IPEX syndrome is likely needed to better understand this possible prenatal presentation.<\/jats:p>","DOI":"10.1002\/jum.14428","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T16:48:10Z","timestamp":1506703690000},"page":"1033-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prenatal Bowel Findings in Male Siblings With a Confirmed <i>FOXP3<\/i> Mutation"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7853-3227","authenticated-orcid":false,"given":"Catherine","family":"Griswold","sequence":"first","affiliation":[{"name":"Carilion Clinic Maternal\u2010Fetal Medicine, Roanoke, Virginia USA; and Virginia Tech Carilion School of Medicine Roanoke Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison R.","family":"Durica","sequence":"additional","affiliation":[{"name":"Carilion Clinic Maternal\u2010Fetal Medicine, Roanoke, Virginia USA; and Virginia Tech Carilion School of Medicine Roanoke Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry G.","family":"Dennis","sequence":"additional","affiliation":[{"name":"Carilion Clinic Maternal\u2010Fetal Medicine, Roanoke, Virginia USA; and Virginia Tech Carilion School of Medicine Roanoke Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann F.","family":"Jewell","sequence":"additional","affiliation":[{"name":"Carilion Clinic Maternal\u2010Fetal Medicine, Roanoke, Virginia USA; and Virginia Tech Carilion School of Medicine Roanoke Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31821aa739"},{"key":"e_1_2_5_3_1","unstructured":"SONOedu.com. 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