{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T07:51:12Z","timestamp":1768636272717,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the parenchymal elasticity of the thyroid gland with acoustic radiation force impulse imaging in pediatric patients with Hashimoto thyroiditis and to compare it with healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six patients with Hashimoto thyroiditis and 26 healthy volunteers between 6 and 17 years were included. The shear wave velocity (SWV) values of both thyroid lobes in both groups were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The age and sex characteristics of the controls and patients with Hashimoto thyroiditis were similar. The SWV of the thyroid gland in patients with Hashimoto thyroiditis (mean\u2009\u00b1\u2009SD, 1.67\u2009\u00b1\u20090.63\u2009m\/s) was significantly higher than that in the control group (1.30\u2009\u00b1\u20090.13\u2009m\/s; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). There was no significant difference between the thyroid lobes in both groups. A receiver operating characteristic curve analyses showed an optimal cutoff value of 1.41\u2009m\/s, with 73.1% sensitivity, 80.8% specificity, a 79.2 % positive predictive value, and a 75.0% negative predictive value (area under the curve, 0.806; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). In patients with Hashimoto thyroiditis, there was a positive correlation between the SWV values versus anti\u2010thyroperoxidase (Pearson <jats:italic>r<\/jats:italic>\u2009=\u20090.46; <jats:italic>P<\/jats:italic>\u2009=\u2009.038). There were no correlations between age, body mass index, thyroid function test results, and anti\u2010thyroglobulin values and versus SWV values. Also, no significant differences were seen between the groups for gland size, gland vascularity, and <jats:sc>l<\/jats:sc>\u2010thyroxine treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acoustic radiation force impulse elastography showed a significant difference in the stiffness of the thyroid gland between children with Hashimoto thyroiditis and the healthy group. Using acoustic radiation force impulse elastography immediately after a standard ultrasound evaluation may predict chronic autoimmune thyroiditis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14459","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T10:46:43Z","timestamp":1508842003000},"page":"1143-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Acoustic Radiation Force Impulse Quantification in the Evaluation of Thyroid Elasticity in Pediatric Patients With Hashimoto Thyroiditis"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1537-9562","authenticated-orcid":false,"given":"Serap","family":"Yucel","sequence":"first","affiliation":[{"name":"Departments of Radiology Ondokuz Mayis University School of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem","family":"Ceyhan Bilgici","sequence":"additional","affiliation":[{"name":"Departments of Radiology Ondokuz Mayis University School of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8989-560X","authenticated-orcid":false,"given":"Cengiz","family":"Kara","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Endocrinology Ondokuz Mayis University School of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulay","family":"Can Yilmaz","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Endocrinology Ondokuz Mayis University School of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Murat","family":"Aydin","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Endocrinology Ondokuz Mayis University School of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muzaffer","family":"Elmali","sequence":"additional","affiliation":[{"name":"Departments of Radiology Ondokuz Mayis University School of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leman","family":"Tomak","sequence":"additional","affiliation":[{"name":"Departments of Medical Biostatistics Ondokuz Mayis University School of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"Saglam","sequence":"additional","affiliation":[{"name":"Departments of Radiology Ondokuz Mayis University School of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1377"},{"key":"e_1_2_6_3_1","first-page":"e12026","article-title":"Preliminary study on the kidney elasticity quantification in patients with chronic kidney disease using Virtual Touch tissue quantification","volume":"12","author":"Zheng XZ","year":"2015","journal-title":"Iran J Radiol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-014-3072-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12373"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-015-0754-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-015-0502-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4274\/tpa.46.83","article-title":"Hashimoto tiroiditli hastalar\u0131m\u0131z\u0131n \u00f6zellikleri","volume":"46","author":"\u00d6zsu E","year":"2011","journal-title":"T\u00fcrk Pediatri Ar\u015fivi"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.20515\/otd.73478"},{"key":"e_1_2_6_10_1","first-page":"95","article-title":"Recommended normative values for thyroid volume in children aged 6\u201315 years","volume":"75","author":"World Health Organization, International Council for Control of Iodine Deficiency Disorders","year":"1997","journal-title":"Bull WHO"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-8266(02)00072-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4329\/wjr.v4.i4.174","article-title":"ARFI elastography for the evaluation of diffuse thyroid gland pathology: preliminary results","volume":"28","author":"Sporea I","year":"2012","journal-title":"World J Radiol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140604"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0736"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.11152\/mu.2013.2066.173.khu"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/164548"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2013.01.023"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.68"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjum.14459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.14459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T18:38:02Z","timestamp":1694284682000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.14459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,24]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/jum.14459"],"URL":"https:\/\/doi.org\/10.1002\/jum.14459","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,24]]},"assertion":[{"value":"2017-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}