{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:51:57Z","timestamp":1764251517973,"version":"3.37.3"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to detect left ventricular (LV) structure and function abnormalities in patients with type 2 diabetes mellitus with or without nonalcoholic fatty liver (NAFL) using 3\u2010dimensional speckle\u2010tracking echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty patients with type 2 diabetes and a normal LV ejection fraction (\u226555%), including 40 with coexistent NAFL, and 40 age\u2010 and sex\u2010matched control participants were recruited. Conventional echocardiography and 3\u2010dimensional speckle\u2010tracking echocardiography were performed, and global longitudinal strain, global circumferential strain, global area strain, and global radial strain values were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences in 2\u2010dimensional LV functional patterns were found among the 3 groups (<jats:italic>P<\/jats:italic>\u2009=\u2009.031), and LV hypertrophy was the most prevalent in patients with diabetes and NAFL. The patients with diabetes only had significantly lower global longitudinal strain, global circumferential strain, and global radial strain than the controls (all<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). The patients with diabetes and NAFL had severely lower global longitudinal strain, global circumferential strain, global area strain, and global radial strain than the controls (all<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and they also had severely lower global longitudinal strain, global area strain, and global radial strain than the patients with diabetes only (all<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The hemoglobin A<jats:sub>1c<\/jats:sub>level and NAFL were independently associated with strain values in all patients with diabetes. The strain values in multiple directions (\u22652 of global longitudinal, global circumferential, global area, and global radial strain) decreased significantly in the patients with diabetes and moderate and severe NAFL compared to those with mild NAFL (all<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nonalcoholic fatty liver could aggravate LV hypertrophy and dysfunction in patients with type 2 diabetes. The combined application of conventional and 3\u2010dimensional speckle\u2010tracking echocardiography could detect these asymptomatic preclinical abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14536","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T09:09:08Z","timestamp":1516784948000},"page":"1899-1911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Nonalcoholic Fatty Liver Is Associated With Further Left Ventricular Abnormalities in Patients With Type 2 Diabetes Mellitus: A 3\u2010Dimensional Speckle\u2010Tracking Study"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6950-0631","authenticated-orcid":false,"given":"Qingqing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Southwest Medical University Luzhou 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