{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:05:12Z","timestamp":1778583912063,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000019","name":"National Hemophilia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Point\u2010of\u2010care musculoskeletal ultrasound (US) is increasingly used by hemophilia providers to guide management; however, pathologic tissue differentiation with US is uncertain. We sought to determine the extent to which point\u2010of\u2010care musculoskeletal US can identify and discriminate pathologic soft tissue changes in hemophilic arthropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010six adult patients with hemophilia A\/B were prospectively enrolled. Point\u2010of\u2010care musculoskeletal US examinations were performed on arthropathic joints (16 knees, 10 ankles, and 10 elbows) using standard views by a musculoskeletal US\u2013trained and certified hematologist, who recorded abnormal intra\u2010articular soft tissue accumulation. Within 3 days, magnetic resonance imaging was performed using conventional and multiecho ultrashort echo time sequences. Soft tissue identification (synovial proliferation with or without hemosiderin, fat, and\/or blood products) was performed by a musculoskeletal radiologist. Findings obtained with both imaging modalities were compared and correlated in a blinded fashion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was perfect agreement between the modalities on the presence of abnormal soft tissue (34 of 36 cases). However, musculoskeletal US was unable to discriminate between coagulated blood, synovium, intrasynovial or extrasynovial fat tissue, or hemosiderin deposits because of wide variations in echogenicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Musculoskeletal US is valuable for point\u2010of\u2010care imaging to determine the presence of soft tissue accumulation in discrete areas. However, because of limitations of musculoskeletal US in discriminating the nature of pathologic soft tissues and detecting hemosiderin, magnetic resonance imaging will be required if such discrimination is clinically important.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.14541","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T05:38:55Z","timestamp":1516772335000},"page":"1945-1956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Advanced Hemophilic Arthropathy: Sensitivity of Soft Tissue Discrimination With Musculoskeletal Ultrasound"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9426-6322","authenticated-orcid":false,"given":"Annette","family":"von Drygalski","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of California San Diego San Diego California USA"},{"name":"Department of Molecular and Experimental Medicine Scripps Research Institute La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy E.","family":"Moore","sequence":"additional","affiliation":[{"name":"General Musculoskeletal Imaging, Inc Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonha","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of California San Diego San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2721-4151","authenticated-orcid":false,"given":"Richard F. W.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of California San Diego San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena M.","family":"Volland","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of California San Diego San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tudor H.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Diego San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Diego San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric 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