{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:39:07Z","timestamp":1792661947907,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to perform an updated analysis of complications associated with upper and lower extremity peripheral nerve blocks (PNBs) performed with ultrasound (US) guidance versus the landmark approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a single\u2010center retrospective cohort analysis to compare the incidence of PNB complications between the techniques. The primary outcome was local anesthetic systemic toxicity (LAST), whereas the secondary outcomes included short\u2010 and long\u2010term nerve injuries. The current query included cases performed between 2012 and 2015. A combined analysis included data extending to 2006. The Statistical examination relied on the \u03c7<jats:sup>2<\/jats:sup> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During this 4\u2010year period, we performed 7789 US\u2010guided and 498 landmark\u2010guided blocks with no statistically significant difference in the incidence of nerve injury or LAST between the groups. Our 10\u2010year analysis, however, revealed a significant increase (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) in the rate of LAST with the landmark technique: 7 of 5932 versus 0 of 16,858 cases. The combined data also revealed a significant increase (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) in short\u2010term injuries associated with the landmark approach (30 of 5932 versus 33 of 16,858) but no significant difference in the incidence of long\u2010term injuries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our analysis supports a conclusion that the use of US guidance during PNBs leads to a significant reduction in the incidence of LAST, adding to growing evidence from similar investigations. The impact of US on the incidence of nerve injuries remains unclear, considering that the nature of transient deficits is thought to be multifactorial, and the frequency of lasting injuries did not differ significantly in this study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14603","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T15:22:45Z","timestamp":1521991365000},"page":"2477-2488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Updated Retrospective Single\u2010Center Comparative Analysis of Peripheral Nerve Block Complications Using Landmark Peripheral Nerve Stimulation Versus Ultrasound Guidance as a Primary Means of Nerve Localization"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6705-5573","authenticated-orcid":false,"given":"Vladyslav","family":"Melnyk","sequence":"first","affiliation":[{"name":"Department of Anesthesiology 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200308000-00025"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen384"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e31825cb3d6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e318292669b"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181a3272c"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e318263d396"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e3181a3438e"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aia.0000166678.25518.a1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000299433.25179.70"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2006.03.010"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet585"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e31826af511"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e31825a9485"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000045"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e3181ccbc96"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182850dc7"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-010-9275-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e3181d2310b"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200305000-00005"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199508000-00020"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000329"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000331"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000334"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2009.05938.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181ea5f5d"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000425"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200110000-00015"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181a59891"}],"container-title":["Journal 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