{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T18:12:25Z","timestamp":1785262345436,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T00:00:00Z","timestamp":1525046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Patients with hematologic malignancies, especially those with acute disease or those receiving intense chemotherapy, are known to develop acute acalculous cholecystitis (AAC). The aim of this study was to evaluate the diagnostic and prognostic value of the established ultrasound (US) diagnostic criteria for AAC in patients with acute hematologic malignancies who were clinically suspected to have AAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied the US findings of the gallbladder in patients with hematologic malignancies and correlated these findings with the duration of clinical symptoms, complications, and gallbladder\u2010specific mortality. The major criteria were a 3.5\u2010mm or thicker wall, pericholecystic fluid, intramural gas, and a sloughed mucosal membrane. The minor criteria were echogenic bile and hydrops (gallbladder distension\u2009&gt;\u20094\u2009cm). Ultrasound findings were considered positive if they included 2 major criteria or 1 major and 2 minor criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010four (25.5%) of 368 patients with hematologic malignancies had clinical signs of AAC during their acute phase of illness or during intense chemotherapy. Forty\u2010three (45.7%) of these 94 patients had AAC\u2010positive test results based on US criteria. The mean duration of symptoms was significantly longer (7.8 days) in this group than among the patients with negative test results (3.9 days; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Patients with positive test results had a higher rate of complications or mortality (20.9%) than those with negative test results (0%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Symptomatic patients who meet the US criteria for the diagnosis of AAC have a poor prognosis. Other patients require a close follow\u2010up US examination within 1 week to detect early progression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14660","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T09:30:15Z","timestamp":1525080615000},"page":"51-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Acute Acalculous Cholecystitis in Hospitalized Patients With Hematologic Malignancies and Prognostic Importance of Gallbladder Ultrasound Findings"],"prefix":"10.1002","volume":"38","author":[{"given":"Rajesh","family":"Thampy","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, Division of Diagnostic Imaging University of Texas Health Science Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Radiology Michael E. DeBakey VA Medical Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam H.","family":"Zaki","sequence":"additional","affiliation":[{"name":"Urology and Nephrology Center Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Texas Health Science Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brinda Rao","family":"Korivi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Division of Diagnostic Imaging University of Texas Health Science Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Staerkel","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Health Science Center Houston Texas 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