{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:41:55Z","timestamp":1792791715107,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T00:00:00Z","timestamp":1525046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671698"],"award-info":[{"award-number":["81671698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the association between shear wave elastography parameters using virtual touch tissue imaging quantification (VTIQ) and the Ki\u201067 index in luminal\u2010type breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010one patients with 82 lesions of pathologic confirmed luminal\u2010type breast cancer underwent virtual touch tissue imaging quantification examination before surgery between December 2015 and June 2016. Patients were divided into 2 groups according to the Ki\u201067 index (\u226514% versus\u2009&lt;\u200914%), which is used to define luminal type B and luminal type A, respectively. The mean shear wave velocity (SWV<jats:sub>mean<\/jats:sub>) and lesion\u2010to\u2010adjacent tissues ratio (SWV ratio) were calculated for each lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SWV<jats:sub>mean<\/jats:sub>, SWV ratio, histologic grade, axillary lymph node involvement, and lymphovascular invasion showed a significant positive association with a high Ki\u201067 index (all <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Receiver operating characteristic curve analysis for the differential diagnosis between high (\u226514%) and low (&lt;14%) Ki\u201067 groups displayed that the optimal cutoff value for SWV<jats:sub>mean<\/jats:sub> and SWV ratio were 3.99 meters per second and 2.861, with sensitivity 94% and 72%, specificity 40.6% and 56.2%, and area under the receiver operating characteristic curve of 0.689 and 0.651, respectively. Univariate analysis showed that SWV<jats:sub>mean<\/jats:sub> (<jats:italic>P<\/jats:italic>\u2009=\u2009.005), SWV ratio (<jats:italic>P<\/jats:italic>\u2009=\u2009.029), histologic grade (<jats:italic>P<\/jats:italic>\u2009=\u2009.011), presence of axillary node involvement (<jats:italic>P<\/jats:italic>\u2009=\u2009.004), and lymphovascular invasion (<jats:italic>P<\/jats:italic>\u2009=\u2009.008) were significantly associated with high Ki\u201067 status. Multivariable analysis displayed that SWV<jats:sub>mean<\/jats:sub> (hazard ratio [HR], 1.459, 95% confidence interval [CI], 1.028\u20132.072; <jats:italic>P<\/jats:italic>\u2009=\u2009.035), histologic grade (HR, 4.105; 95% CI, 1.142\u201314.763; <jats:italic>P<\/jats:italic>\u2009=\u2009.031), and presence of axillary node involvement (HR, 3.75; 95% CI, 1.228\u201311.453; <jats:italic>P<\/jats:italic>\u2009=\u2009.020) maintained significance for predicting high Ki\u201067 status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SWV<jats:sub>mean<\/jats:sub> using the virtual touch tissue imaging quantification method showed significant correlation with the Ki\u201067 index, suggesting the potential to assess tumor proliferation status in luminal\u2010type breast cancer with a noninvasive manner.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14663","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T09:39:18Z","timestamp":1525081158000},"page":"73-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association Between Shear Wave Elastography of Virtual Touch Tissue Imaging Quantification Parameters and the Ki\u201067 Proliferation Status in Luminal\u2010Type Breast Cancer"],"prefix":"10.1002","volume":"38","author":[{"given":"Yubo","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Ultrasound Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 6 Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yini","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Sun Yat\u2010Sen University Cancer 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