{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:45:22Z","timestamp":1782773122091,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,5,6]],"date-time":"2018-05-06T00:00:00Z","timestamp":1525564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM109090"],"award-info":[{"award-number":["P20GM109090"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to determine whether sciatic nerve stiffness is altered in people with chronic low back\u2013related leg pain by using shear wave elastography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, the sciatic nerve shear wave velocity (ie, an index of stiffness) was measured in both legs of 16 participants (8 with unilateral low back\u2013related leg pain and 8 healthy controls). Sciatic stiffness was measured during a passive ankle dorsiflexion motion performed at 2\u00b0\/s in an isokinetic dynamometer. The ankle range of motion and passive torque, as well as muscle activity, were also measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In people with low back\u2013related leg pain, the affected limb showed higher sciatic nerve stiffness compared to the unaffected limb (+11.3%; <jats:italic>P<\/jats:italic>\u2009=\u2009.05). However, no differences were observed between the unaffected limb of people with low back\u2013related leg pain and the healthy controls (<jats:italic>P<\/jats:italic>\u2009=\u2009.34).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>People with chronic low back\u2013related leg pain have interlimb differences in sciatic nerve stiffness, as measured by a safe and noninvasive method: shear wave elastography. The changes found may be related to alterations in nerve mechanical properties, which should be confirmed by future investigations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14679","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T06:50:50Z","timestamp":1525675850000},"page":"157-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Noninvasive Measurement of Sciatic Nerve Stiffness in Patients With Chronic Low Back Related Leg Pain Using Shear Wave Elastography"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6696-5372","authenticated-orcid":false,"given":"Tiago","family":"Neto","sequence":"first","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Motricidade Humana Lisbon Portugal"},{"name":"LUNEX International University of Health, Exercise and Sports, Department of Physiotherapy Differdange Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9760-5350","authenticated-orcid":false,"given":"Sandro R.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Motricidade Humana Lisbon Portugal"},{"name":"Human Performance Department. Benfica Laboratory, Sport Lisboa e Benfica Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo J.","family":"Andrade","sequence":"additional","affiliation":[{"name":"University of Nantes, Laboratory of Movement, Interactions, and Performance, Faculty of Sport Sciences Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o R.","family":"Vaz","sequence":"additional","affiliation":[{"name":"Human Performance Department. Benfica Laboratory, Sport Lisboa e Benfica Lisbon Portugal"},{"name":"Universidade Europeia, Laureate International Universities Lisbon Portugal"},{"name":"Department of Biomechanics and Center for Human Movement Variability University of Nebraska Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-2711","authenticated-orcid":false,"given":"Bruno","family":"Mendes","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Motricidade Humana Lisbon Portugal"},{"name":"Human Performance Department. Benfica Laboratory, Sport Lisboa e Benfica Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Telmo","family":"Firmino","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Motricidade Humana Lisbon Portugal"},{"name":"Human Performance Department. 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