{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:22:59Z","timestamp":1785583379454,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,5,6]],"date-time":"2018-05-06T00:00:00Z","timestamp":1525564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the role of transvaginal ultrasound (TVUS) for diagnosing cervical invasion in the preoperative assessment of endometrial carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search for studies evaluating the role of TVUS for assessing cervical invasion in endometrial carcinoma from January 1990 to December 2016 was performed in the PubMed\/MEDLINE, Web of Science, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ClinicalTrials.gov\">www.ClinicalTrials.gov<\/jats:ext-link>, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.who.int\/trialsearchdatabases\">www.who.int\/trialsearchdatabases<\/jats:ext-link>. The quality of the studies was evaluated by the Quality Assessment of Diagnostic Accuracy Studies 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 211 citations. Ultimately, 17 studies comprising 1751 women were included. The mean prevalence of cervical invasion was 16.3%. The risk of bias was high in 7 studies for the domains \u201cpatient selection\u201d and \u201cindex test,\u201d whereas it was considered low for the \u201creference test\u201d domain. Overall, the pooled estimated sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of TVUS for detecting cervical invasion were 63% (95% confidence interval [CI], 51%\u201374%), 91% (95% CI, 87%\u201394%), 10.2 (95% CI, 5.7\u201318.3), and 0.38 (95% CI, 0.28\u20130.53), respectively. Heterogeneity was high for both sensitivity and specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transvaginal ultrasound has acceptable diagnostic performance for detecting cervical invasion in women with endometrial carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14682","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T06:51:39Z","timestamp":1525675899000},"page":"179-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diagnostic Performance of Transvaginal Ultrasound for Detecting Cervical Invasion In Women With Endometrial Carcinoma: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9700-0853","authenticated-orcid":false,"given":"Juan Luis","family":"Alc\u00e1zar","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital Fundaci\u00f3n Jimenez\u2010Diaz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"G\u00fcell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital Santa Caterina de Salt Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Haro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital Santa Caterina de Salt Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Manzour","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Chacon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Jurado","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,6]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"IARC Cancer Base. 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