{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:38:35Z","timestamp":1789141115555,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Polish Ministry of Science and Higher Education as a research project of the Military Institute of Medicine","award":["N N402 473840"],"award-info":[{"award-number":["N N402 473840"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Endothelial dysfunction has been implicated in the pathogenesis of cerebral small\u2010vessel disease (SVD). Little is known about the relationship between SVD and measures of endothelium\u2010dependent vasodilatation and cerebral vasomotor reactivity. The aim of this study was to evaluate cerebral and extracerebral endothelial dysfunction in patients with different manifestations of SVD and to assess the relationship between endothelial dysfunction and radiologic markers of SVD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The vasomotor reactivity reserve (VMRr), breath\u2010holding index (BHI) of the middle cerebral arteries, and brachial artery flow\u2010mediated dilatation (FMD) were measured with ultrasound techniques in 90 patients (30 in each group) older than 60 years with extensive white matter lesions (Fazekas grade\u2009\u2265\u20092) with a history of lacunar stroke, vascular dementia, or parkinsonism and 30 individuals with normal magnetic resonance imaging findings (control group). All groups were matched for age, sex, hypertension, and diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age\u2009\u00b1\u2009SD (71.8\u2009\u00b1\u20093.4 versus 71.7\u2009\u00b1\u20093.4 years), sex distribution, and prevalence of the main vascular risk factors were similar in the SVD and control groups. The VMRr (56.6%\u2009\u00b1\u200918.3% versus 77.1%\u2009\u00b1\u200916.9%), BHI (0.8\u2009\u00b1\u20090.3 versus 1.1\u2009\u00b1\u20090.4), and FMD (5.8%\u2009\u00b1\u20094 versus 12.1%\u2009\u00b1\u20095.2%) were severely impaired in the SVD groups compared to the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). The vascular responses to all tests was similar in the SVD groups, but they were significantly decreased in patients with severe white matter lesions, marked brain atrophy, and enlarged perivascular spaces.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study was the first that simultaneously evaluated cerebral and extracerebral vasodilator responses in a well\u2010phenotyped cohort of patients with lacunar stroke, vascular dementia, or parkinsonism. The VMRr, BHI, and FMD were more severely impaired in patients with SVD, regardless of its clinical manifestation, than in control participants. All measures were significantly lower in patients with severe white\u2010matter lesions, brain atrophy, or enlarged perivascular spaces.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14782","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T16:39:11Z","timestamp":1536770351000},"page":"975-987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Cerebral and Extracerebral Vasoreactivity in Patients With Different Clinical Manifestations of Cerebral Small\u2010Vessel Disease: Data From the Significance of Hemodynamic and Hemostatic Factors in the Course of Different Manifestations of Cerebral Small\u2010Vessel Disease Study"],"prefix":"10.1002","volume":"38","author":[{"given":"Jacek","family":"Staszewski","sequence":"first","affiliation":[{"name":"Clinic of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Skrobowska","sequence":"additional","affiliation":[{"name":"Department of Radiology Military Institute of Medicine  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Piusi\u0144ska\u2010Macoch","sequence":"additional","affiliation":[{"name":"Clinic of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Brodacki","sequence":"additional","affiliation":[{"name":"Clinic of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"St\u0119pie\u0144","sequence":"additional","affiliation":[{"name":"Clinic of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70104-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000312"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00014.2006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70060-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.4.924"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.1.96"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.8.963"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.151574"},{"key":"e_1_2_6_10_1","first-page":"65","article-title":"Cerebral hemodynamics in acute stroke: pathophysiology and clinical implications","volume":"1","author":"Tsivgoulis G","year":"2008","journal-title":"J Vasc Interv Neurol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/424695"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.15344\/2394-4978\/2015\/140"},{"key":"e_1_2_6_13_1","first-page":"81","volume-title":"Parkinsonian Syndromes","author":"Hurtig HI","year":"1993"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.473"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20083"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01746-6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi017"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097034"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2002.tb00129.x"},{"key":"e_1_2_6_20_1","first-page":"1929","article-title":"Changes in blood flow velocity and diameter of the middle cerebral artery during hyperventilation: assessment with MR and transcranial Doppler sonography","volume":"18","author":"Valdueza JM","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1331812"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.5.668"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000837"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-008-1119-2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_6_27_1","unstructured":"GoblirschG BershowS CummingsK et al.Institute for Clinical Systems Improvement. 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