{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:18:40Z","timestamp":1768562320514,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600669"],"award-info":[{"award-number":["81600669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2016J01646"],"award-info":[{"award-number":["2016J01646"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the applicability and value of ultrasound (US) in the diagnosis of anorectal atresia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2008 and January 2016, we prospectively evaluated 63,101 fetuses (gestational age, 20\u201338 weeks), including low\u2010 and high\u2010risk populations using 2\u2010dimensional US scans. An abnormal imaging finding was defined as an anal canal diameter of less than the 95% confidence interval (small anal canal) of the normal range or the absence of an anal canal and rectum. Imaging findings were considered normal on detection of an anal canal with a normal width and the absence of abnormalities. Prenatal imaging findings were confirmed by a postnatal or postmortem examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the investigated fetuses, 28 showed evidence of anorectal atresia on US scans, and 22 of those with anorectal atresia had additional anomalies. Six cases of isolated anorectal atresia were successfully detected during the preclusive prenatal US scans. Four cases of a low imperforate anus (including 2 covered anuses) yielded false\u2010negative results, indicating a diagnostic rate of 87.5% (28 of 32). The normal appearance of the fetal rectum and anal canal ruled out anorectal atresia in 30 fetuses with a dilated colon. Additionally, there were 3 false\u2010positive cases, in which a narrow anal canal was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Identifying the abnormal appearance or absence of the fetal anal canal and rectum on preclusive US anomaly scans is useful for prenatal diagnosis or exclusion of anorectal atresia, which may help improve the detection of isolated anorectal atresia. Furthermore, a combined evaluation of the longitudinal and axial appearances of the fetal anal canal and rectum can improve diagnostic accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14836","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T04:24:54Z","timestamp":1538540694000},"page":"1501-1509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prenatal Evaluation for Detection of Anorectal Atresia: Value of Ultrasound"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-4299","authenticated-orcid":false,"given":"Yi\u2010Ming","family":"Su","sequence":"first","affiliation":[{"name":"Departments of Ultrasound First Affiliated Hospital of Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Fujian Provincial Maternity and Children's Hospital of Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8605-8139","authenticated-orcid":false,"given":"Shu\u2010Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound First Affiliated Hospital of Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics First Affiliated Hospital of Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3123-1138","authenticated-orcid":false,"given":"Guo\u2010Rong","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Quanzhou Medical College  Quanzhou China"},{"name":"Department of Ultrasound Second Affiliated Hospital of Fujian Medical University  Quanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Rong","family":"Lin","sequence":"additional","affiliation":[{"name":"Departments of Ultrasound First Affiliated Hospital of Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.6.576"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.155.5.587"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3862"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.2.395"},{"key":"e_1_2_6_6_1","first-page":"331","article-title":"Associated malformations in cases with congenital diaphragmatic hernia","volume":"19","author":"Stoll C","year":"2008","journal-title":"Genet 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