{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:46:41Z","timestamp":1792226801355,"version":"4.4.0"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health Resources and Services Administration service","award":["H30MC24045"],"award-info":[{"award-number":["H30MC24045"]}]},{"name":"Veterans Affairs","award":["I01CX001388"],"award-info":[{"award-number":["I01CX001388"]}]},{"name":"Veterans Affairs","award":["I01RX002604"],"award-info":[{"award-number":["I01RX002604"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Musculoskeletal ultrasound (US) is used increasingly to examine hemophilic arthropathy. However, quantitative algorithms to document findings are lacking. We developed and sought to validate a protocol quantifying hemophilic joint abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010one patients with hemophilia were examined serially for 2 years with musculoskeletal US (\u2248600 joint examinations and \u22486000 images). Based on the spectrum of pathologies, a quantitative algorithm, named Joint Tissue Activity and Damage Examination (JADE), was developed for soft tissue and osteochondral measurements, including power Doppler, using nominal group techniques. To study intra\u2010 and inter\u2010rater reliability, 8 musculoskeletal US\u2013experienced hemophilia providers performed anatomic landmark recognition and tissue measurements on 86 images with arthropathic changes, with repetition 1 month later. Twenty\u2010three musculoskeletal US\u2013inexperienced providers performed similar assessments. Inter\u2010operator reliability was established by 6 musculoskeletal US\u2013experienced hemophilia providers, each acquiring images and JADE assessments of 3 hemophilic arthropathic joints. A radiologist and musculoskeletal sonographer functioned as adjudicators. The statistical analysis was performed with the intraclass correlation coefficient (ICC), Fleiss \u03ba, and Cohen \u03ba where appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The musculoskeletal US\u2013experienced providers showed excellent intra\u2010and inter\u2010rater reliability for tissue measurements (ICCs, 0.94\u20130.96). Agreement was good to excellent for landmark recognition (Fleiss \u03ba, 0.87\u20100.94). Inter\u2010operator reliability was excellent for measurements and landmark recognition (ICC, 0.90; Fleiss \u03ba, 1.0). Agreement with adjudicators was mostly good to excellent. Musculoskeletal US\u2013inexperienced providers showed excellent inter\u2010rater reliability for measurements (ICC, 0.96) and moderate agreement for landmark recognition (Fleiss \u03ba, 0.58).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The JADE protocol appears feasible for quantifying hemophilic intra\u2010articular abnormalities. Musculoskeletal US\u2013trained hemophilia providers showed high intra\u2010rater, inter\u2010rater, and inter\u2010operator reliability, supporting JADE as a protocol for clinical management and research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.14846","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T08:47:27Z","timestamp":1540802847000},"page":"1569-1581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Development and Reliability of the Joint Tissue Activity and Damage Examination for Quantitation of Structural Abnormalities by Musculoskeletal Ultrasound in Hemophilic Joints"],"prefix":"10.1002","volume":"38","author":[{"given":"Lena M.","family":"Volland","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny Y.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F. 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