{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:05:52Z","timestamp":1775840752234,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61401102"],"award-info":[{"award-number":["61401102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81627804"],"award-info":[{"award-number":["81627804"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830058"],"award-info":[{"award-number":["81830058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify clinicopathologic and ultrasound (US) variables that were associated with a heavy nodal tumor burden, which was defined as 3 or more lymph nodes involved with metastasis to the axilla after invasive breast carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>With ethical approval, 621 patients with a pathologic diagnosis of invasive breast carcinoma were retrospectively analyzed for clinical, pathologic, and US data. Pathologic findings were ascertained by the final paraffin pathologic analysis. Ultrasound characteristics were evaluated on the basis of the American College of Radiology's Breast Imaging Reporting and Data System (BI\u2010RADS). Univariate and multivariate logistic regression analyses were used to assess the clinicopathologic and US variables that were associated with a heavy nodal tumor burden at the axilla.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 107 cases (17.2%) of invasive breast carcinoma with a heavy tumor burden at the axilla. The independent clinicopathologic variables for a heavy tumor burden at the axilla included a tumor size of 2 to 5\u2009cm (odds ratio [OR], 1.86; <jats:italic>P<\/jats:italic>\u2009=\u2009.036), the presence of lymphovascular invasion (OR, 23.52; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), the presence of papillary invasion (OR, 2.93; <jats:italic>P<\/jats:italic>\u2009=\u2009.043), and a non\u2013triple\u2010negative subtype (OR, 2.34; <jats:italic>P<\/jats:italic>\u2009=\u2009.04). The independent US features of breast tumors that were associated with a heavy tumor burden at the axilla included BI\u2010RADS category 5 (OR, 5.50; <jats:italic>P<\/jats:italic>\u2009=\u2009.024) and a posterior acoustic shadow (OR, 1.94; <jats:italic>P<\/jats:italic>\u2009=\u2009.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A large tumor size, lymphovascular invasion, papillary invasion, and a non\u2013triple\u2010negative subtype on the pathologic analysis as well as BI\u2010RADS category 5 and a posterior acoustic shadow on a US assessment were associated with a heavy nodal tumor burden at the axilla. These US characteristics of the primary breast carcinoma might provide additional information to axillary US for the prediction of axillary nodal tumor loads.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14863","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T12:45:21Z","timestamp":1543322721000},"page":"1747-1755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinicopathologic and Ultrasound Variables Associated With a Heavy Axillary Nodal Tumor Burden in Invasive Breast Carcinoma"],"prefix":"10.1002","volume":"38","author":[{"given":"Jia\u2010wei","family":"Li","sequence":"first","affiliation":[{"name":"Departments of Medical Ultrasound  Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010yang","family":"Tong","sequence":"additional","affiliation":[{"name":"Departments of Medical Ultrasound  Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010zhou","family":"Jiang","sequence":"additional","affiliation":[{"name":"Breast Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu\u2010juan","family":"Shui","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, Wenzhou People's Hospital, Third Clinical Institute affiliated with Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao\u2010ting","family":"Shi","sequence":"additional","affiliation":[{"name":"Departments of Medical Ultrasound  Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4914-733X","authenticated-orcid":false,"given":"Cai","family":"Chang","sequence":"additional","affiliation":[{"name":"Departments of Medical Ultrasound  Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-2-480"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1555872"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.90"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14545"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2012.11.005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-2-350"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2013_045"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2007.09.017"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3813-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4717-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.9479"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2468-3"},{"key":"e_1_2_6_14_1","first-page":"35","article-title":"Classification and grading of invasive breast carcinoma","volume":"89","author":"Elston CW","year":"2005","journal-title":"Verh Dtsch Ges Pathol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt303"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020297"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890101)63:1<181::AID-CNCR2820630129>3.0.CO;2-H"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2017.10.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26711"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4741.2003.09107.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0606-2"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.07.702"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-3045"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6874-13-47"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22312"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2012.11.002"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12928"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1999.18.5.363"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2015.14515"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.21990"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860801971413"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.02088.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-004-1478-6"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185117723039"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjum.14863","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.14863","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.14863","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.14863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T12:11:42Z","timestamp":1694347902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.14863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/jum.14863"],"URL":"https:\/\/doi.org\/10.1002\/jum.14863","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,27]]},"assertion":[{"value":"2018-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}