{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:07:51Z","timestamp":1792030071342,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the association between the ultrasound (US) characteristics of breast tumors with axillary lymph node metastasis (ALNM) and Ki\u201067 expression in patients with breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 527 consecutive patients with breast cancer who had undergone US examinations and curative surgery with axillary lymph node evaluations were included. The size, shape, aspect ratio, margin, internal echo, internal calcification, posterior echo attenuation, lymphatic hilar structure, cortical thickness, and blood flow of the axillary lymph nodes or primary breast lesions were observed with conventional US. Pathologic prognostic factors, including the histologic type of the tumor, histologic grade, estrogen and progesterone receptor status, lymph node status, and Ki\u201067 expression were determined. A logistic regression model was used to evaluate whether the US characteristics of primary breast lesions were associated with ALNM and Ki\u201067 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The maximum tumor diameter (odds ratio [OR], 1.54; 95% confidence interval [CI], 1.05\u20132.27; <jats:italic>P<\/jats:italic>\u2009=\u2009.028), tumor margin (OR, 2.89; 95% CI, 1.69\u20134.94; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), internal echo (OR, 2.17; 95% CI, 1.47\u20133.20; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and Ki\u201067 status (OR, 3.57; 95% CI, 2.29\u20135.58; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) had significant value as independent predictors of ALNM. Only the internal echo (OR, 1.95; 95% CI, 1.28\u20132.95; <jats:italic>P<\/jats:italic>\u2009=\u2009.002) of breast cancer was an independent predictor of the Ki\u201067 status. The heterogeneity in the internal echo indicated faster cancer cell proliferation and was associated with a worse prognosis in patients with breast carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Certain conventional US characteristics may be useful predictors of ALNM and the Ki\u201067 status in patients with breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14879","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T15:41:39Z","timestamp":1543333299000},"page":"1833-1840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Correlation of Conventional Ultrasound Characteristics of Breast Tumors With Axillary Lymph Node Metastasis and Ki\u201067 Expression in Patients With Breast Cancer"],"prefix":"10.1002","volume":"38","author":[{"given":"Hang","family":"Zhang","sequence":"first","affiliation":[{"name":"the Department of Ultrasound, 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