{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:19:10Z","timestamp":1789708750713,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate whether abdominal ultrasound (US) with a gallbladder (GB) contractility study or motor function test can be used as a diagnostic tool in patients with dengue and warning signs in acute and recovery phases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010one individuals in the acute phase of dengue presenting with warning signs (dengue group) and 49 healthy individuals without a history of dengue or hepatobiliary disease (control group) were studied with abdominal US and a GB contractility study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistical differences in US measurements of the liver (right lobe, <jats:italic>P<\/jats:italic>\u2009=\u2009.012; left lobe, <jats:italic>P<\/jats:italic>\u2009=\u2009.001) and spleen (<jats:italic>P<\/jats:italic>\u2009=\u2009.008) dimensions, GB wall thickness (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and the GB emptying fraction (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) were observed in dengue during the acute phase compared with the control group. After 60\u2009days, abdominal US of the dengue group showed a statistical difference in liver (right lobe, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001; left lobe, <jats:italic>P<\/jats:italic>\u2009=\u2009.078) and spleen (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) dimensions, GB wall thickness, and the GB emptying fraction (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) compared with the results obtained during the acute phase. Furthermore, a statistical difference in the spleen volume and GB emptying fraction (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) was observed when comparing dengue after clinical recovery and the control group. Abdominal pain in patients with dengue was positively associated with hepatomegaly (<jats:italic>P<\/jats:italic>\u2009=\u2009.031), splenomegaly (<jats:italic>P<\/jats:italic>\u2009=\u2009.008), increased GB wall thickness (<jats:italic>P<\/jats:italic>\u2009=\u2009.016), and a reduced GB emptying fraction (<jats:italic>P<\/jats:italic>\u2009=\u2009.038) during the acute phase and with splenomegaly (<jats:italic>P<\/jats:italic>\u2009=\u2009.001) and a reduced GB emptying fraction (<jats:italic>P<\/jats:italic>\u2009=\u2009.003) after clinical recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abdominal US with a GB motor function test can be used as a diagnostic tool in patients with dengue during acute and recovery phases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14890","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T12:58:16Z","timestamp":1544792296000},"page":"2015-2024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ultrasound Assessment of Hepatobiliary and Splenic Changes in Patients With Dengue and Warning Signs During the Acute and Recovery Phases"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9263-8439","authenticated-orcid":false,"given":"Bruno Doriguetto Couto","family":"Ferreira","sequence":"first","affiliation":[{"name":"Divisions of Radiology Federal University of Tri\u00e2ngulo Mineiro  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalmo","family":"Correia","sequence":"additional","affiliation":[{"name":"Infectious Diseases Federal University of Tri\u00e2ngulo Mineiro  Uberaba 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