{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:41:20Z","timestamp":1782913280229,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006098","name":"Radiological Society of North America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether quantitative contrast\u2010enhanced ultrasound (CEUS) can accurately identify neonates and infants with hypoxic ischemic brain injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective cohort study, 8 neonates and infants with a suspicion of hypoxic ischemic injury were evaluated with CEUS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An interesting trend was observed in the central gray nuclei\u2013to\u2013cortex perfusion ratios. The ratios at the peak enhancement, wash\u2010in area under the curve, perfusion index, and maximum wash\u2010in slopes were lower in all of the affected cases compared to the normal group but not statistically significant given the small sample size (<jats:italic>P<\/jats:italic>\u2009=\u2009.0571). Additionally, when the central gray nuclei\u2013to\u2013cortex perfusion ratio was plotted for all time points along the time\u2010intensity curve, it was observed that the affected cases showed a trend that was qualitatively different from that of the normal cases. In the affected cases, the ratio time\u2010intensity curves either stayed below 1.0 for the entire enhancement period or reached 1.0 close to peak wash\u2010in before falling just below 1.0 for the remaining period of enhancement. However, in the unaffected patients, there was a steep wash\u2010in that crossed the 1.0 threshold and remained above 1.0 for most of the enhancement period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bedside CEUS is an easily obtainable brain\u2010imaging modality that has the potential to effectively identify infants and neonates with evolving brain injury. A larger prospective study evaluating the correlation between CEUS findings and the reference standard of diffusion\u2010 and perfusion\u2010weighted magnetic resonance imaging is needed to establish it as a diagnostic tool.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14892","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T03:26:10Z","timestamp":1545103570000},"page":"2025-2038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Novel Quantitative Contrast\u2010Enhanced Ultrasound Detection of Hypoxic Ischemic Injury in Neonates and Infants: Pilot Study 1"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0125-2686","authenticated-orcid":false,"given":"Misun","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Radiology, Children's Hospital of Philadelphia, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anush","family":"Sridharan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children's Hospital of Philadelphia, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassa","family":"Darge","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children's Hospital of Philadelphia, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becky","family":"Riggs","sequence":"additional","affiliation":[{"name":"Department of Pediatric Anesthesiology and Critical Care Medicine Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Radiology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Flibotte","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Children's Hospital of Philadelphia, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry A. 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