{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:42:54Z","timestamp":1773344574289,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Diagnostic ultrasound (DUS) imaging can induce pulmonary capillary hemorrhage (PCH), possibly related to the ultrasonic radiation surface pressure arising from reflection at the lung blood\u2010air interfaces. Acoustic radiation force impulse (ARFI) elastography is a relatively new DUS mode with high\u2010energy \u201cpush pulses\u201d used to move tissue and generate shear waves. The objective of this study was to characterize PCH induced by the ARFI elastographic mode for comparison with other previously tested DUS modes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pulmonary capillary hemorrhage induction was examined for ARFI elastographic frames with 5.7\u2010MHz push pulses (Acuson S3000; Siemens Medical Solutions, Mountain View, CA), which had a derated PRPA of 2.6\u2009MPa. Groups of rats with tracheal tube placement had no ventilation (spontaneous breathing), intermittent positive pressure ventilation (IPPV), or IPPV plus 8\u2009cm H<jats:sub>2<\/jats:sub>O of positive end\u2010expiratory pressure (PEEP). Exposure was to 1 or 20 manually triggered image frame acquisitions. The PCH area was measured on the lung surface.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 20\u2010frame exposure groups, and even the single\u2010frame group, had significant PCH relative to shams. Single\u2010frame exposures produced significantly less PCH (<jats:italic>P<\/jats:italic>\u2009=\u2009.002) than 20\u2010frame exposures in rats with a tracheal tube only (spontaneous breathing). The PEEP inhibited the PCH and produced about half of the PCH area induced for IPPV without PEEP (<jats:italic>P<\/jats:italic>\u2009=\u2009.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The PCH results were comparable with those from a previous study using B\u2010mode or color Doppler exposure for 5\u2009minutes; however, these modes delivered many more pulses for continuous imaging frames, suggesting that the ARFI elastographic frames were individually much more effective.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14950","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T14:33:15Z","timestamp":1548945195000},"page":"2575-2587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pulmonary Capillary Hemorrhage Induced by Acoustic Radiation Force Impulse Shear Wave Elastography in Ventilated Rats"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0707-0637","authenticated-orcid":false,"given":"Douglas L.","family":"Miller","sequence":"first","affiliation":[{"name":"Departments of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Dong","sequence":"additional","affiliation":[{"name":"Departments of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Dou","sequence":"additional","affiliation":[{"name":"Departments of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3748-3865","authenticated-orcid":false,"given":"Brandon","family":"Patterson","sequence":"additional","affiliation":[{"name":"Departments of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnan","family":"Raghavendran","sequence":"additional","affiliation":[{"name":"Departments of Surgery University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2012.04.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(90)90046-F"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2000.19.2.97"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2008.27.4.565"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v2.i2.83"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2013.32.1.165"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000096"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2016.06.021"},{"key":"e_1_2_6_10_1","first-page":"105","volume-title":"Critical Care Ultrasound","author":"Ahmad S","year":"2015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2015.09.003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1570353"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2017.11.006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2016.08.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2015.01.016"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspa.2007.0308"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022112007004648"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/57\/23\/8061"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.34.2.289"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2018.04.014"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S0022-5223(19)35741-1","article-title":"Effect of positive end\u2010expiratory pressure on alveolar capillary perfusion","volume":"95","author":"Nieman GF","year":"1988","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-303642"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1287706"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2014.12.022"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2013.2617"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2015.03.009"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2015.03.008"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2015.03.007"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2005.1561624"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2011.0023"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2004.1320828"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/016173460402600203"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2013.11.015"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10396-016-0730-0"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2003.08.002"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2015.03.030"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2016.03.012"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.34.7.15.13.0001"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.5067441"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjum.14950","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.14950","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.14950","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.14950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T22:15:58Z","timestamp":1694297758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.14950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,31]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/jum.14950"],"URL":"https:\/\/doi.org\/10.1002\/jum.14950","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,31]]},"assertion":[{"value":"2018-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}