{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:36:48Z","timestamp":1784875008865,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["FRQS\u2010ARQ 31144"],"award-info":[{"award-number":["FRQS\u2010ARQ 31144"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["#RGPIN\u20102016\u201005212"],"award-info":[{"award-number":["#RGPIN\u20102016\u201005212"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the accuracy of homodyned K quantitative ultrasound (QUS) with that of B\u2010mode and Doppler ultrasound imaging for discriminating between lateral epicondylosis (LE) and asymptomatic elbows.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study received Institutional Review Board approval, and participants provided written informed consent. Between February 2015 and March 2017, 30 LE elbows in 27 patients and 24 asymptomatic elbows in 13 volunteers underwent B\u2010mode, Doppler, and radiofrequency ultrasound imaging of the common extensor tendon (CET) and radial collateral ligament (RCL). Two readers classified the elbows independently on the basis of a review of B\u2010mode and Doppler images. The global and local estimates of QUS parameters (\u03bc<jats:sub><jats:italic>n<\/jats:italic><\/jats:sub>, 1\/\u03b1, and<jats:italic>k<\/jats:italic>) were computed in the CET and CET\u2010RCL regions, respectively, and the area of each region was calculated. A random\u2010forest classifier identified the most discriminating 3\u2010parameter combination: CET global estimate of 1\/\u03b1, CET\u2010RCL area, and local estimate of<jats:italic>k<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients with LE had a mean age of 50\u2009years (range, 31\u201366\u2009years), and the volunteers had a mean age of 50\u2009years (range, 37\u201357\u2009years). The area under the receiver operating characteristic curve, sensitivity, and specificity of reader 1, reader 2, and the QUS\u2010based model were 0.80 (95% confidence interval [CI], 0.66\u20130.95), 0.72 (95% CI, 0.56\u20130.89), and 0.88 (95% CI, 0.72\u20131.04); 0.79 (95% CI, 0.66\u20130.93), 0.65 (95% CI, 0.47\u20130.82), and 0.84 (95% CI, 0.67\u20131.01); and 0.82 (95% CI, 0.80\u20130.85), 0.73, and 0.79, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An automated, computer\u2010based QUS technique diagnosed LE with accuracy of 0.82. This technique could provide quantitative biomarkers for the characterization of LE disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.14964","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T05:49:43Z","timestamp":1549518583000},"page":"2631-2641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Diagnostic Accuracy of Echo Envelope Statistical Modeling Compared to B\u2010Mode and Power Doppler Ultrasound Imaging in Patients With Clinically Diagnosed Lateral Epicondylosis of the Elbow"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3710-9280","authenticated-orcid":false,"given":"Nathalie J.","family":"Bureau","sequence":"first","affiliation":[{"name":"Departments of Radiology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"},{"name":"Departments of Research Center Centre Hospitalier de l'Universit\u00e9 de 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