{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:21:31Z","timestamp":1788211291131,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To document changes in the median nerve cross\u2010sectional area (CSA) in the proximal carpal tunnel region after ultrasound (US)\u2010guided carpal tunnel release (CTR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective data were collected on 23 consecutive patients (37 wrists) treated with US\u2010guided CTR by the primary author using the same office\u2010based microinvasive technique. Ultrasound was used to measure the largest CSA of the median nerve in the proximal carpal tunnel region both preoperatively and postoperatively. The primary outcome measure was the change in the preoperative versus 6\u2010 to 10\u2010week postoperative median nerve CSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean CSA of the median nerve decreased from 16.08 to 12.75\u2009mm<jats:sup>2<\/jats:sup> at 6 to 10\u2009weeks after US\u2010guided CTR (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). During the same period, the mean Boston Carpal Tunnel Questionnaire (BCTQ) symptom score decreased from 3.23 to 1.67 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and mean BCTQ functional score decreased from 2.49 to 1.47 (<jats:italic>P<\/jats:italic> &lt; .001), both exceeding minimal clinically important differences. Although the primary end point was the median nerve CSA at 6 to 10\u2009weeks, statistically significant reductions in the median nerve CSA, as well as BCTQ scores, were also observed as early as 2 to 4\u2009weeks after US\u2010guided CTR (median nerve CSA, 12.40\u2009mm<jats:sup>2<\/jats:sup>; BCTQ symptom score, 2.00; BCTQ functional score, 1.75; all <jats:italic>P<\/jats:italic>\u2009\u2264 .03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, this investigation was the largest to date examining changes in the proximal median nerve CSA after US\u2010guided CTR. Statistically significant reductions in the proximal median nerve CSA were observed within 6 to 10\u2009weeks after ultrasound\u2010guided CTR. These reductions were similar to those previously reported for open and endoscopic CTR and validate the ability of US\u2010guided CTR to relieve median nerve compression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15146","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T08:43:55Z","timestamp":1572338635000},"page":"693-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Ultrasound (US) Changes in the Median Nerve Cross\u2010Sectional Area After Microinvasive US\u2010Guided Carpal Tunnel Release"],"prefix":"10.1002","volume":"39","author":[{"given":"Craig D.","family":"Chappell","sequence":"first","affiliation":[{"name":"In2it Medical Pleasant Grove  Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4657-5953","authenticated-orcid":false,"given":"John 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