{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:59:04Z","timestamp":1765976344570,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the value of grayscale and power Doppler ultrasound (PDUS) in the evaluation of carpal tunnel syndrome (CTS) in clinically suspected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010seven wrists of 61 patients with clinically suspected CTS and 57 wrists of 30 healthy control participants were included in our study. Median nerve (MN) cross\u2010sectional area (CSA) measurements were performed at the tunnel inlet level (wCSA) and proximal pronator quadratus muscle level (fCSA). Two parameters were calculated: CSA absolute difference (\u0394CSA), which was the difference between the two measurements; and CSA ratio (RCSA), calculated by dividing wCSA over fCSA. The MN at the wrist level was evaluated for hypervascularity with PDUS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean wCSA, R\u2010CSA, and \u0394CSA values were significantly higher in patients (17\u2009mm<jats:sup>2<\/jats:sup>, 2.45, and 9.9\u2009mm<jats:sup>2<\/jats:sup>, respectively) than in control participants (8\u2009mm<jats:sup>2<\/jats:sup>, 1.29, and 1.65\u2009mm<jats:sup>2<\/jats:sup>; (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). At their corresponding cutoff values, the wCSA yielded higher sensitivity (95%) and lower specificity (88%) compared to the RCSA and \u0394CSA (89% and 93% sensitivity and 93% and 89% specificity). Power Doppler US was the most specific US parameter (100%) but the least sensitive (76%). A multivariate logistic regression model including the wCSA, RCSA, and PDUS yielded 97% diagnostic accuracy at their optimal cutoffs, which increased to 99% after eliminating age and body mass index confounding effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of MN swelling measurements and PDUS increases the diagnostic accuracy of US in patients with clinically suspected CTS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15200","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T12:32:15Z","timestamp":1576758735000},"page":"1155-1162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Value of Grayscale and Power Doppler High\u2010Resolution Ultrasound in Assessment of Patients with Clinically Suspected Carpal Tunnel Syndrome"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-1962","authenticated-orcid":false,"given":"Amr Mohamed","family":"Gamil","sequence":"first","affiliation":[{"name":"Department of Radiodiagnosis Egyptian National Institute of Neuromotor System  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mennatallah Hatem","family":"Shalaby","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled Ali","family":"Shehata","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Mohamed","family":"El Deeb","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Al Azhar University  Cairo 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