{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:34Z","timestamp":1786978174114,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>First arch syndromes are congenital defects caused by failure of neural crest cells to migrate into the first branchial arch. First arch syndrome is classified into 2 main clinical manifestations: Treacher Collins syndrome, characterized by bilateral underdevelopment of the zygomatic bones; and Pierre Robin sequence. The aim of this study was to describe the feasibility of visualization of the fetal zygomatic bone and assess its application in cases referred for features suggestive of first arch syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study was conducted. The feasibility of visualization of the zygomatic bone was performed in 50 sequential fetuses with a normal anatomic scan between 12 and 24\u2009weeks' gestation using 3\u2010dimensional sonography. Following this, cases referred for targeted scans for suspected first branchial arch syndrome were assessed for the presence or absence of the zygomatic bones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Visualization of the fetal zygomatic bone was feasible in all low\u2010risk cases. Cases referred for targeted scans included 11 isolated cases of micrognathia or retrognathia, 3 cases of microtia, and 3 cases of auricular or facial vestiges. Within this group, the zygomatic bones were visualized in all but 2 cases. No associated extrafacial malformations were detected; therefore, this phenotype was consistent with Treacher Collins syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prenatal imaging of the zygomatic bones offers a clinically based sonographic approach to cases referred for features suggestive of first arch syndrome and enables differentiation between the 2 main clinical manifestations: Treacher Collins syndrome and Pierre Robin sequence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.15325","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T07:14:03Z","timestamp":1588835643000},"page":"2165-2172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Imaging of the Fetal Zygomatic Bone"],"prefix":"10.1002","volume":"39","author":[{"given":"Yinon","family":"Gilboa","sequence":"first","affiliation":[{"name":"Ultrasound Unit, Helen Schneider Women's Hospital Rabin Medical Center  Petach Tikva Israel"},{"name":"Tel\u2010Aviv University Sackler School of Medicine  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuven","family":"Achiron","sequence":"additional","affiliation":[{"name":"Tel\u2010Aviv University Sackler School of Medicine  Tel\u2010Aviv Israel"},{"name":"Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology Chaim Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvi","family":"Kivilevitch","sequence":"additional","affiliation":[{"name":"Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology Chaim Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Hochberg","sequence":"additional","affiliation":[{"name":"Ultrasound Unit, Helen Schneider Women's Hospital Rabin Medical Center  Petach Tikva Israel"},{"name":"Tel\u2010Aviv University Sackler School of Medicine  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4545-7234","authenticated-orcid":false,"given":"Ron","family":"Bardin","sequence":"additional","affiliation":[{"name":"Ultrasound Unit, Helen Schneider Women's Hospital Rabin Medical Center  Petach Tikva Israel"},{"name":"Tel\u2010Aviv University Sackler School of Medicine  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Zalel","sequence":"additional","affiliation":[{"name":"Tel\u2010Aviv University Sackler School of Medicine  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-0679","authenticated-orcid":false,"given":"Sharon","family":"Perlman","sequence":"additional","affiliation":[{"name":"Ultrasound Unit, Helen Schneider Women's Hospital Rabin Medical Center  Petach Tikva Israel"},{"name":"Tel\u2010Aviv University Sackler School of Medicine  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"143","volume-title":"The Developing Human Clinically Oriented Embryology","author":"Moore K","year":"2019"},{"key":"e_1_2_6_3_1","first-page":"395","volume-title":"The Developing Human Clinically Oriented Embryology","author":"Moore K","year":"2019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34352"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000380948"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2017.06.043"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00622.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7639"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-0128(98)00023-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5151"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.10715"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2073"},{"key":"e_1_2_6_13_1","unstructured":"Online Mendelian Inheritance in Man. Treacher Collins syndrome 1; TCS1. Online Mendelian Inheritance in Man website.https:\/\/omim.org\/entry\/154500. Updated April 16 2018."},{"key":"e_1_2_6_14_1","unstructured":"Online Mendelian Inheritance in Man. Treacher Collins syndrome 3; TCS3. Online Mendelian Inheritance in Man website.https:\/\/omim.org\/entry\/248390. Updated January 28 2011."},{"key":"e_1_2_6_15_1","unstructured":"Online Mendelian Inheritance in Man. Treacher Collins syndrome 2; TCS2. Online Mendelian Inheritance in Man website.https:\/\/omim.org\/entry\/613717. Updated February 24 2016."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.29"},{"key":"e_1_2_6_17_1","unstructured":"Online Mendelian Inheritance in Man. Pierre Robin syndrome; PRBNS. Online Mendelian Inheritance in Man website.https:\/\/omim.org\/entry\/261800. Updated June 5 2014."},{"key":"e_1_2_6_18_1","unstructured":"Monarch Initiative. Hypoplasia of the zygomatic bone. Monarch Initiative website; 2020.https:\/\/monarchinitiative.org\/phenotype\/HP:0010669#disease."},{"key":"e_1_2_6_19_1","unstructured":"Online Mendelian Inheritance in Man. Postaxial acrofacial dysostosis; POADS. Online Mendelian Inheritance in Man website.https:\/\/omim.org\/entry\/263750. Updated June 3 2010."},{"key":"e_1_2_6_20_1","unstructured":"Online Mendelian Inheritance in Man. Acrofacial dysostosis 1 Nager type; AFD1. Online Mendelian Inheritance in Man website.https:\/\/omim.org\/entry\/154400. Updated March 9 2015."},{"key":"e_1_2_6_21_1","unstructured":"Online Mendelian Inheritance in Man. Ablepharon\u2010macrostomia syndrome; AMS. Online Mendelian Inheritance in Man website.https:\/\/omim.org\/entry\/200110. Updated September 25 2015."},{"key":"e_1_2_6_22_1","unstructured":"Online Mendelian Inheritance in Man. Hemifacial microsomia; HFM. Online Mendelian Inheritance in Man website.https:\/\/omim.org\/entry\/164210. 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