{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:28:48Z","timestamp":1747150128944,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Aplasia and hypoplasia of the major salivary glands, particularly the parotid glands, were reported to be associated with trisomy 21. This study aimed to evaluate the value of first\u2010trimester nonvisualization of the parotid gland in a high\u2010risk population of fetuses with increased nuchal translucency (NT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center prospective observational cohort study was conducted. The feasibility of imaging the parotid gland was assessed in 100 sequential cases of routine low\u2010risk NT scans. In a 2\u2010dimensional image in an axial plane at the level of the fetal mandible, the parotid glands appear as bilateral hyperechoic round areas. Cases referred for counseling for an NT measured above the 95th percentile for gestational age were evaluated for visualization of the parotid glands. Prenatal findings were correlated with fetal genetic analysis results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two cases with increased NT constituted the final study group. Within the group with nonvisualization of the parotid gland, genetic testing revealed 9 cases of trisomy 21, 3 cases of trisomy 18, and 1 case of monosomy X. The sensitivity and specificity of nonvisualization of the parotid gland as a predictor of aneuploidy were 76% and 80%, respectively. The positive likelihood ratio, negative likelihood ratio, and relative risk were 3.82 (95% confidence interval [CI], 1.67\u20138.74), 0.29 (95% CI, 0.12\u20130.71), and 4.33 (95% CI, 1.69\u201311.09; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). The negative predictive value was 95.14%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>First\u2010trimester nonvisualization of the parotid gland may constitute a potential method for detection of aneuploid fetuses within a high\u2010risk population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15371","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T14:52:34Z","timestamp":1592405554000},"page":"41-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>First\u2010Trimester<\/scp> Nonvisualization of the Parotid Gland and Aneuploidy in Fetuses With Increased Nuchal Translucency"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-0679","authenticated-orcid":false,"given":"Sharon","family":"Perlman","sequence":"first","affiliation":[{"name":"Helen Schneider Women's Hospital, Rabin Medical Center Ultrasound Unit  Petach Tikva Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivka","family":"Sukenik\u2010Helevy","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Rabin Medical Center Raphael Recanati Genetic Institute  Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan","family":"Odeh","sequence":"additional","affiliation":[{"name":"Ultrasound Unit, Obstetrics and Gynecology Department Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrat","family":"Keren Gilat","sequence":"additional","affiliation":[{"name":"Helen Schneider Women's Hospital, Rabin Medical Center Ultrasound Unit  Petach Tikva Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University  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