{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:35:51Z","timestamp":1760189751918,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Increasing studies have reported focal chemotherapy\u2010induced sinusoidal injury (CSI) mimicking colorectal liver metastasis (CRLM) on imaging studies, resulting in unnecessary lobectomy. This study aimed to investigate the contrast\u2010enhanced ultrasound (CEUS) imaging features of focal CSI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated 16 patients who had a pathologic diagnosis of focal CSI and underwent CEUS between January 2013 and January 2019. The images were compared with those obtained from 27 patients with CRLM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On CEUS, 14 (87.5%) focal CSIs showed heterogeneous isoenhancement, 1 (6.3%) peripheral hyperenhancement, and 1 (6.3%) homogeneous hyperenhancement during the arterial phase. Compared with the adjacent liver parenchyma, the initial enhancement time of focal CSI was earlier in 2 (12.5%), simultaneous in 9 (56.3%), and later in 5 (31.3%) patients. In the portal and late phases, all of the focal CSI cases showed hypoenhancement compared with the adjacent liver parenchyma. Focal CSI had the following CEUS findings, which were different from those of CRLM: (1) heterogeneous isoenhancement in the arterial phase (87.5% versus 0%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001); (2) an initial enhancement time later than that of the liver parenchyma (mean\u2009\u00b1\u2009SD, 0.5\u2009\u00b1\u20091.5 versus \u22121.5\u2009\u00b1\u20091.9; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001); (3) a longer time to peak (30.5\u2009\u00b1\u20095.6 versus 22.5\u2009\u00b1\u20094.4\u2009seconds; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001); and (4) a later time to wash\u2010out (51.0\u2009\u00b1\u200912.5 versus 35.0\u2009\u00b1\u20096.2\u2009seconds; <jats:italic>P<\/jats:italic> = .002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Focal CSI usually shows heterogeneous isoenhancement in arterial phase and hypoenhancement in portal and late phases on CEUS, with slow contrast wash\u2010in and wash\u2010out, which can be helpful in the differential diagnosis with CRLM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15384","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T13:29:36Z","timestamp":1595424576000},"page":"141-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>Contrast\u2010Enhanced<\/scp> Ultrasound Imaging Features of Focal <scp>Chemotherapy\u2010Induced<\/scp> Sinusoidal Injury in Patients With Colorectal Cancer"],"prefix":"10.1002","volume":"40","author":[{"given":"Si","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasonics Sixth Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics Sixth Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou 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