{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:37:49Z","timestamp":1783049869787,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shenzhen Science and Technology project","award":["JCYJ20170307091013214"],"award-info":[{"award-number":["JCYJ20170307091013214"]}]},{"name":"the National Key Research and Development Program of China","award":["2018YFC1002202"],"award-info":[{"award-number":["2018YFC1002202"]}]},{"DOI":"10.13039\/501100001809","name":"the National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81571758"],"award-info":[{"award-number":["81571758"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81771598"],"award-info":[{"award-number":["81771598"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to determine the sensitivity of a first\u2010trimester routine scan in detecting spina bifida (SB) and evaluating the first\u2010trimester intracranial signs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study was a review of a prospectively collected database. All cases of SB diagnosed in a tertiary center from 2008 to 2015 were identified. The ultrasound images and medical records were reviewed. All cases of SB diagnosed prenatally were confirmed at birth or autopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 24 cases of SB were diagnosed from 53,349 pregnancy cases. Except for 10 cases with a body stalk anomaly, craniorachischisis, or iniencephaly, 7 cases with open spina bifida (OSB) and 7 cases with closed spina bifida (CSB) were analyzed. The first\u2010trimester detection rates were 100% (7 of 7) for OSB and 28.5% (2 of 7) for CSB. Eight cases were highly suspected of SB in the first trimester because of an abnormal appearance of the posterior brain; 3 were false\u2010positive cases. Two isolated cases of OSB had first\u2010trimester intracranial signs. An obliterated cisterna magna (CM) showed the highest sensitivity for OSB but low specificity. Two cases of OSB had no discernible landmark of intracranial translucency and the CM, and 4 showed normal intracranial translucency with an obliterated CM. All CSB cases were coupled with a normal hind brain except for 2 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A first\u2010trimester routine scan has high sensitivity in screening for OSB. The CM may be the most sensitive intracranial sign.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15392","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T12:20:20Z","timestamp":1595334020000},"page":"237-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Fetal Open and Closed Spina Bifida on a Routine Scan at 11\u2009Weeks to 13\u2009Weeks 6\u2009Days"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4073-3500","authenticated-orcid":false,"given":"Yimei","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Ultrasound and Central Laboratory, Shenzhen Maternity and Child Healthcare Hospital First School of Clinical Medicine, Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxuan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of 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Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound and Central Laboratory, Shenzhen Maternity and Child Healthcare Hospital First School of Clinical Medicine, Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound and Central Laboratory, Shenzhen Maternity and Child Healthcare Hospital First School of Clinical Medicine, Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound and Central Laboratory, Shenzhen Maternity and Child Healthcare Hospital First School of Clinical Medicine, Southern Medical University  Shenzhen 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