{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:29:03Z","timestamp":1747150143210,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine contrast enhancing features of mediastinal masses (ML) using transcutaneous contrast\u2010enhanced ultrasound (CEUS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of n = 58 patients with histologically confirmed ML, which were examined in the period from October 2005 to February 2018 using transcutaneous B\u2010mode ultrasound and CEUS. In n = 29 (50%) histological confirmation was performed by ultrasound guided core\u2010needle biopsy. The lesions were evaluated using CEUS in regard to the enhancement pattern (hyper\u2010, iso\u2010, hypoenhancement, non\u2010enhancement, homogenous, inhomogenous) compared to enhancement of the spleen as an in vivo reference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>N = 53 (91.4%) of ML were malignant (m) (lymphoma n = 36, metastasis n = 11, thymoma n = 2, teratoma n = 1, sarcoma n = 2, seminoma n = 1). In n = 5 (8.6%) cases there was a benign (b) histology (thyroid tissue n = 2, thymus residue n = 1, ganglioneurinoma n = 1, scar tissue: n = 1). In ultrasound, n = 53 (91.4%; (48 = m, 5 = b)) were hypoechoic, n = 5 (8.6%, (5 = m,0 = b)) hyperechoic. In CEUS, n = 35 lesions presented an arterial isoenhancement (60.3%; 33 = m, 2 = b). An arterial hypoenhancement had n = 21 (36.2%, (20 = m,1 = b)), and no enhancement showed n = 2 (3.5%, (0 = m, 2 = b) of the ML. A parenchymal isoenhancement was observed in n = 1 (1.7%, (1 = m, 0 = b)), a hypoenhancement in n = 54 (93.1%; 51 = m, 3 = b) of the patients and almost no enhancement in n = 3 ML (5.2%, (1 = m, 2 = b).) The enhancement was homogeneous in n = 26 (44.8%, (25 = m,1 = b)) cases, in n = 31 (53.5%, (28 = m,3 = b)) inhomogeneous and n = 1 (1.7%) benign lesion was exclusively cystic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In CEUS, mediastinal tumor formations showed variable arterial enhancement, followed by parenchymal hypoenhancement (wash\u2010out).<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15479","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T13:01:00Z","timestamp":1600779660000},"page":"1023-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mediastinal Masses in <scp>Contrast\u2010Enhanced<\/scp> Ultrasound \u2010 Retrospective Analysis of 58 Cases"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4573-7802","authenticated-orcid":false,"given":"Corinna","family":"Trenker","sequence":"first","affiliation":[{"name":"Zentrum f\u00fcr Innere Medizin, Klinik f\u00fcr H\u00e4matologie, Onkologie und Immunologie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg, Standort Marburg und Philipps\u2010Universit\u00e4t Marburg  Baldingersta\u00dfe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph Frank","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department Allgemeine Innere Medizin (DAIM), Kliniken Hirslanden Beau Site, Salem und Permanence  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lique","family":"Holland","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Innere Medizin, Klinik f\u00fcr Pneumologie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg, Standort Marburg und Philipps\u2010Universit\u00e4t Marburg  Baldingerstra\u00dfe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Schulte","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Innere Medizin, Interdisziplin\u00e4res Ultraschallzentrum Universit\u00e4tsklinikum Gie\u00dfen und Marburg, Standort Marburg und Philipps\u2010Universit\u00e4t Marburg  Baldingerstra\u00dfe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Michel","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Innere Medizin, Klinik f\u00fcr H\u00e4matologie, Onkologie und Immunologie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg, Standort Marburg und Philipps\u2010Universit\u00e4t Marburg  Baldingersta\u00dfe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"G\u00f6rg","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Innere Medizin, Interdisziplin\u00e4res Ultraschallzentrum Universit\u00e4tsklinikum Gie\u00dfen und Marburg, Standort Marburg und Philipps\u2010Universit\u00e4t Marburg  Baldingerstra\u00dfe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"532","article-title":"Diagnostic imaging of mediastinal tumors. 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