{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:14:56Z","timestamp":1792192496210,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To observe the microvascular architecture in the placental bed and explore the feasibility and clinical utility of MV\u2010Flow imaging (Samsung Medison Co, Ltd, Seoul, Korea) during normal pregnancy and fetal growth restriction (FGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Placental microvascular structure ultrasound imaging by MV\u2010Flow was performed on 227 unaffected and 17 FGR fetuses between 11 and 41\u2009weeks' gestation. A placental vascular index (VI<jats:sup>MV<\/jats:sup>) was acquired by application of various MV\u2010Flow regions of interest (ellipse, rectangle, and manual trace). Unaffected control and FGR groups were assessed for umbilical artery, middle cerebral artery, and uterine artery pulsatility indices and the cerebroplacental ratio calculated by ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference in the VI<jats:sup>MV<\/jats:sup> by varying regions of interest or placental regions was observed in the control group. The VI<jats:sup>MV<\/jats:sup> in the first trimester was lower than that in the second and third trimesters, with 5th through 95th percentile normal VI<jats:sup>MV<\/jats:sup> reference values of 18.39 to 63.79 for 13.6\u2009weeks and earlier, 28.53 to 66.64 for 14\u2009weeks to 27\u2009weeks 6\u2009days, and 21.95 to 67.45 for 28\u2009weeks and later. The VI<jats:sup>MV<\/jats:sup> values in the FGR group were lower than those in the control group in the upper, middle, and lower parts of the placenta (mean\u2009\u00b1\u2009SD, 24.9\u2009\u00b1\u200913.9 versus 45.0\u2009\u00b1\u200913.4; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01; 30.5\u2009\u00b1\u200916.1 versus 44.7\u2009\u00b1\u200914.3; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01; and 29.9\u2009\u00b1\u200917.4 versus 47.6\u2009\u00b1\u200912.2; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01, respectively). Higher umbilical artery and uterine artery pulsatility indices and a lower cerebroplacental ratio were found in the FGR group compared with the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MV\u2010Flow technology can display and quantify placental microvascular architecture at the level of the stem villi and villous leaves, and the VI<jats:sup>MV<\/jats:sup> provides for quantification of tissue vascularity. MV\u2010Flow is a potentially powerful and promising tool to explore placental microvascular perfusion and provide new information on a host of pregnancy\u2010related conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15531","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T17:37:52Z","timestamp":1603129072000},"page":"1533-1542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Characterization of Placental Microvascular Architecture by <scp>MV\u2010Flow<\/scp> Imaging in Normal and Fetal Growth\u2013Restricted Pregnancies"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6871-7524","authenticated-orcid":false,"given":"Xinlin","family":"Chen","sequence":"first","affiliation":[{"name":"Maternal and Child Health Hospital of Hubei Province  Wuhan 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 Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"First People's Hospital of Jinzhong  Jingzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Tian","sequence":"additional","affiliation":[{"name":"Fetal Heart Program, Division of Cardiology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Rychik","sequence":"additional","affiliation":[{"name":"Fetal Heart Program, Division of Cardiology Children's Hospital of Philadelphia  Philadelphia Pennsylvania 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