{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:50:15Z","timestamp":1790502615257,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901759"],"award-info":[{"award-number":["81901759"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2019CFB461"],"award-info":[{"award-number":["2019CFB461"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), has become a global pandemic, raising widespread public health concerns. Our team treated hospitalized patients with COVID\u201019 in Wuhan, where the outbreak first began, and we suspected that SARS\u2010CoV\u20102 may cause testicular infection in male patients. We conducted this study to explore that observation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled male patients with a confirmed diagnosis of COVID\u201019 and performed a bedside ultrasound (US) examination of the scrotum, focused on findings of acute inflammation such as tunica albuginea thickening, enlargement and heterogeneous echogenicity of the testis, epididymis, or both, an abscess, scrotal wall edema, and hydrocele. Then we compared the proportions of observed epididymo\u2010orchitis in patients from different age groups and COVID\u201019 severity groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 142 patients with COVID\u201019 were enrolled in our study, and 32 (22.5%) patients had acute orchitis, epididymitis, or epididymo\u2010orchitis on scrotal US imaging, according to the diagnosis criteria. The observed risk of acute scrotal infection increased with age, with the incidence reaching 53.3% in men older than 80\u2009years. We also observed that men with severe COVID\u201019 had a significantly higher possibility of epididymo\u2010orchitis compared to the nonsevere COVID\u201019 group (<jats:italic>P\u2009=\u2009.037<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows US imaging evidence that SARS\u2010CoV\u20102 may cause infection of the testis or epididymis, and the risk is worthy of the attention of clinicians.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15558","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T13:08:01Z","timestamp":1605100081000},"page":"1787-1794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Ultrasound Imaging Findings of Acute Testicular Infection in Patients With Coronavirus Disease 2019"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-018X","authenticated-orcid":false,"given":"Liao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ultrasound Imaging Wuhan University Renmin Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Imaging Wuhan University Renmin Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuohuizi","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Wuhan University Renmin Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Imaging Wuhan University Renmin Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Imaging Wuhan University Renmin Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangli","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Imaging Wuhan University Renmin Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Imaging Wuhan University Renmin Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Imaging Wuhan University Renmin Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Imaging Wuhan University Renmin Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Imaging Wuhan University Renmin Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30185-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30260-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30154-9"},{"key":"e_1_2_6_5_1","unstructured":"World Health Organization website.https:\/\/www.who.int\/. 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