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Ultrasound has been extensively used for the diagnosis of <jats:italic>Schistosoma<\/jats:italic>\u2010related PPF and a number of staging methods have been validated for this purpose such as Strickland classification and Niamey protocol. Nevertheless, the application of noninvasive techniques, particularly elastography modalities, has not been well explored. In this review, we describe the various noninvasive diagnostic tools for assessment of <jats:italic>Schistosoma<\/jats:italic>\u2010related PPF including US parameters, serum biomarkers, and US\u2010based elastography techniques. While elastography techniques have demonstrated value in the evaluation of HSS, the evidence remains limited with most studies recruiting a small number of patients. Longitudinal studies with larger sample size are required in order to devise robust criteria to accurately assess the performance of noninvasive techniques in the prediction of both regression and progression of the degree of PPF and identify their cost\u2010effectiveness in community screening.<\/jats:p>","DOI":"10.1002\/jum.15623","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T23:41:35Z","timestamp":1610754095000},"page":"2273-2287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Noninvasive Assessment of <i>Schistosoma<\/i>\u2010Related Periportal Fibrosis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4379-5064","authenticated-orcid":false,"given":"Ahmed","family":"Hashim","sequence":"first","affiliation":[{"name":"Hepatology Department Royal Free Hospital  London 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