{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:29:03Z","timestamp":1747207743199,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To standardize a new technique to evaluate the fetal leg muscle trophism by measuring the area and circumference, and comparing this technique between normal and fetuses with open lumbosacral spina bifida (SB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Observational cross\u2010sectional study was carried out on pregnant women with 26\u2009weeks who were divided into two groups: Group I\u2014fetuses with diagnosis of open lumbosacral SB; Group II\u2014normal fetuses (control). In fetuses with SB, subjective evaluation of the lower limbs was performed (muscle echogenicity and leg movements). To estimate the leg muscle trophism, the measurement of the area and circumference of the leg were standardized, and the reproducibility of this method was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one fetuses with open lumbosacral SB and 51 normal fetuses were evaluated. The measurements of the area and circumference of the leg proved to be highly reproducible (intraclass correlation coefficient\u2014ICC\u2009&gt;\u20090.95). The leg area and circumference measurements were statistically lower in the SB group than in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). When subjective ultrasound assessment demonstrated hypotrophy of the lower limbs, the measurements of the area and circumference of the leg were statistically lower when compared to normal fetuses (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Fetuses with open SB with abnormal lower limb movements had lower measurements of the area and circumference of the leg than fetuses with normal movements (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A new technique for estimating fetal leg muscle trophism was standardized, which proved to be highly reproducible and was able to show the difference between normal and fetuses with SB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15715","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T11:38:18Z","timestamp":1617277098000},"page":"377-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Measurement of the Area and Circumference of the Leg"],"prefix":"10.1002","volume":"41","author":[{"given":"H\u00e9rbene Jos\u00e9 Figuinha","family":"Milani","sequence":"first","affiliation":[{"name":"Department of Obstetrics Paulista School of Medicine \u2010 Federal University of S\u00e3o Paulo (EPM\u2010UNIFESP)  S\u00e3o Paulo Brazil"},{"name":"Department of Fetal Medicine Hospital e Maternidade Santa Joana  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enoch Quinder\u00e9","family":"de S\u00e1 Barreto","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine Maternity School of Vila Nova Cachoeirinha  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Paulista School of Medicine \u2010 Federal University of S\u00e3o Paulo (EPM\u2010UNIFESP)  S\u00e3o Paulo 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