{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:11Z","timestamp":1786978091483,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis investigated the accuracy of prenatal fetal ultrasound (US) to detect cleft palate during the second and third trimester (12\u201336\u2009weeks) of pregnancy in high\u2010risk fetuses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pubmed and Embase databases were searched for studies that performed prenatal fetal US (comparator) and postnatal examination (reference standard) in fetuses at high risk for orofacial clefts. Risk of bias among included studies was assessed using the QUADAS\u20102. Area under the summary receiver operating characteristic (SROC) curve and pooled sensitivity and specificity were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This meta\u2010analysis included 7 studies involving 663 high\u2010risk fetuses. The individual studies showed that prenatal fetal US accurately predicted the possibility of cleft palate in these fetuses. Pooled sensitivity was 87% (95% CI 71%\u201395%), pooled specificity was 98% (95%CI 90%\u2013100%), and the area under the SROC curve was 0.98 (95% CI 0.97\u20130.99).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Second and third trimester fetal US has excellent sensitivity and specificity for the detection of cleft palate in high\u2010risk pregnancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.15736","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T09:05:26Z","timestamp":1619514326000},"page":"605-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diagnostic Accuracy of Prenatal Fetal Ultrasound to Detect Cleft Palate in High\u2010Risk Fetuses"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-3053","authenticated-orcid":false,"given":"Guang\u2010ping","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Ultrasound Qinzhou Maternal and Child Health Hospital  Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun\u2010jin","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Qinzhou Maternal and Child Health Hospital  Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Qinzhou Maternal and Child Health Hospital  Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010feng","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Qinzhou Maternal and Child Health Hospital  Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010hua","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Qinzhou Maternal and Child Health Hospital  Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13291"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2013.12.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1597\/04-101R.1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.75.895.750584"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.2000.3330"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1766"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7739"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10139"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gyobfe.2015.10.009"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/2000656X.2012.668773"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8933"},{"key":"e_1_2_6_15_1","unstructured":"MaarseWBS PistoriusL.Diagnostic Accuracy of Transabdominal Ultrasound in Detecting Prenatal Cleft Lip and Palate: A Systematic Review. 2010; in: Database of Abstracts of Reviews of Effects (DARE): Quality\u2010Assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22994"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-813102"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3870"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.217.1.r00oc18236"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3877"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7484"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1819"},{"key":"e_1_2_6_23_1","unstructured":"WongHS PringleKC.Ultrasound Imaging of the Fetal Palate Ultrasound Imaging\u2014Medical Applications Igor V. Minin and Oleg V. Minin IntechOpen. DOI:https:\/\/doi.org\/10.5772\/18306. Available fromhttps:\/\/www.intechopen.com\/books\/ultrasound-imaging-medical-applications\/ultrasound-imaging-of-the-fetal-palate."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-019-03500-x"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.15736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.15736","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.15736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:50:39Z","timestamp":1692953439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.15736"}},"subtitle":["A Systematic Review and Meta\u2010Analysis"],"short-title":[],"issued":{"date-parts":[[2021,4,27]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/jum.15736"],"URL":"https:\/\/doi.org\/10.1002\/jum.15736","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,27]]},"assertion":[{"value":"2020-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}