{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:51:02Z","timestamp":1770918662586,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of the first\u2010trimester ultrasound scan in the detection of fetal structural anomalies in twin pregnancies. To examine the association between increased nuchal translucency (NT) thickness, crown\u2013rump length (CRL) or NT discordance, and detection of structural anomalies in a large twin series in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed retrospective analysis of twin pregnancies who underwent 11\u201313<jats:sup>+6<\/jats:sup>\u2010week and second\u2010trimester anomaly scan and booked at Beijing Obstetrics and Gynecology Hospital between January 2012 and December 2016. Measurement of fetal CRL\/NT and assessment of fetal anatomic structures were based on standard (not detailed) protocols. Conjoined twins and twin\u2010reversed arterial perfusion sequence (TRAPS) were excluded from structural anomalies. The diagnostic performance of first\u2010trimester ultrasound in detection of fetal structural anomalies in twins was determined and compared with that of second trimester. The accuracy of independent variates associated with structural anomaly detection was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1442 women with twin pregnancies were included. In 40 women and 45 fetuses, structural anomalies were found. Fetal structural anomalies verified at delivery were detected in 42.5% (17\/40) of affected pregnancies in the first trimester and 92.5% (37\/40) of affected pregnancies when added second trimester (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.13). The survival rate of pregnancies detected in second trimester was higher than that of pregnancies detected in first trimester (11.8% vs 65.2%). The mean value of intertwin CRL\/NT discordance in cases with fetal structural anomalies was larger in monochorionic twins than dichorionic twins, but monochorionicity was not associated with structural anomalies. CRL discordance \u226510% (OR 3.1, 95%CI 1.5\u20136.3) and NT \u226595th centile (OR 20.0, 95%CI 9.0\u201344.2) were associated with fetal structural anomalies. In both dichorionic (DC) and monochorionic (MC) twins, the percentages of CRL discordance \u226510% was larger in twins with structural anomalies than those without structural anomalies (37.5% vs 13.4% in DC twins and 50.0% vs 12.5% in MC twins), and this was also true for NT \u226595th centile (31.3% vs 1.7% in DC twins and 37.5% vs 2.2% in MC twins). In the setting of CRL discordance \u226510%, 40.0% (16\/40) of twins with structural anomalies were found, in which the predominant fetal structural anomalies were cardiovascular defects, abdominal wall defects, and central nervous system defects. The AUC for detecting structural anomalies by CRL discordance \u226510% was 0.63. In the setting of NT \u226595th centile, 32.5% (13\/40) of twins with structural anomalies were found, in which the predominant fetal structural anomalies were cardiovascular defects, cystic hygroma, and abdominal wall defects. The AUC for detecting structural anomalies by NT \u226595th centile was 0.65.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The detection rate of twins with fetal structural anomalies was 42.5% per pregnancy in the first trimester. CRL discordance \u226510% and NT \u226595th centile may indicate higher risk of fetal structural anomalies in twins, but their efficacy was limited.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15784","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T12:40:43Z","timestamp":1626871243000},"page":"971-982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Crown\u2013Rump Length Discordance, Increased Nuchal Translucency, and Detection of Fetal Structural Anomalies in Twin Pregnancies in the First Trimester: 5\u2009Years of Experience in a Tertiary Hospital in China"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4822-7899","authenticated-orcid":false,"given":"Xiaofei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"},{"name":"Department of Ultrasound Beijing Maternal and Child Health Care Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5632-7905","authenticated-orcid":false,"given":"Yinghua","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"},{"name":"Department of Ultrasound Beijing Maternal and Child Health Care Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2241-6774","authenticated-orcid":false,"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"},{"name":"Department of Ultrasound Beijing Maternal and Child Health Care Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"},{"name":"Department of Ultrasound Beijing Maternal and Child Health Care Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8143-2232","authenticated-orcid":false,"given":"Aris T.","family":"Papageorghiou","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women's &amp; Reproductive Health University of Oxford Oxford UK"},{"name":"St George's University Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6836-9192","authenticated-orcid":false,"given":"Qingqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"},{"name":"Department of Ultrasound Beijing Maternal and Child Health Care Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"528","article-title":"Preterm births in Peking Union Medical College Hospital in the Past 25\u2009years","volume":"38","author":"Jiang F","year":"2016","journal-title":"Zhong guo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32745"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23156"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den104"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2007.26.11.1491"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.06.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3760\/cma.j.issn.0366-6999.20122795","article-title":"Ultrasound screening of fetal structural abnormalities by standard ultrasound views during the first trimester","volume":"126","author":"Wang L","year":"2013","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17246"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13017"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21938"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.04.005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.33.1.135"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.09.375"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12430"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13335"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2642"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12342"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8956"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15821"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8831"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5299"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3918"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000015"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17487"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2010.29.10.1439"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12534"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2011-0250"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.4038\/cmj.v55i3.2291"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.101"},{"key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.3109\/14767058.2015.1107901","article-title":"Intertwin crown\u2010rump length discordance in the prediction of fetal anomalies, fetal loss and adverse perinatal outcome","volume":"29","author":"Grande M","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199801)18:1<29::AID-PD213>3.0.CO;2-N"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.093"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7498"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1375\/twin.12.6.605"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21935"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.15784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.15784","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.15784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T18:17:30Z","timestamp":1725473850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.15784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,21]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/jum.15784"],"URL":"https:\/\/doi.org\/10.1002\/jum.15784","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,21]]},"assertion":[{"value":"2021-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}