{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:11:38Z","timestamp":1785600698526,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the diagnostic performance of LR\u20105 for diagnosing poorly differentiated hepatocellular carcinoma (p\u2010HCC). To build a contrast\u2010enhanced ultrasound (CEUS) signature for improving the differential diagnostic performance between p\u2010HCC and intrahepatic cholangiocarcinoma (ICC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The B\u2010mode ultrasound (BUS) and CEUS features of 60 p\u2010HCCs and 56 ICCs were retrospectively analyzed. The CEUS LI\u2010RADS category was assigned according to CEUS LI\u2010RADS v2017. A diagnostic CEUS signature was built based on the independent significant features. An ultrasound (US) signature combining both BUS and CEUS features was also built. The diagnostic performances of the CEUS signature, US signature, and LR\u20105 were evaluated by receiver operating characteristic (ROC) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One (1.7%) p\u2010HCC and 26 (46.4%) ICC patients presented cholangiectasis or cholangiolithiasis (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Fifty\u2010four (90.0%) p\u2010HCCs and 8 (14.3%) ICCs showed clear boundaries in the artery phase (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The washout times of p\u2010HCCs and ICCs were 81.0\u2009\u00b1\u200942.5\u2009s and 34.7\u2009\u00b1\u20098.6\u2009s, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The AUC, sensitivity, and specificity of the CEUS signature, US signature, and LR\u20105 were 0.955, 91.67%, and 90.57% versus 0.976, 96.67%, and 92.45% versus 0.758, 51.67%, and 100%, respectively. The AUC and sensitivity of CEUS LI\u2010RADS were much lower than those of the CEUS and US signatures (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LR\u20105 had high specificity but low sensitivity in diagnosing p\u2010HCC. When the washout time and tumor boundary were included in the CEUS signature, the sensitivity and AUC were remarkably increased in the differentiation between p\u2010HCC and ICC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15812","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T14:46:18Z","timestamp":1629729978000},"page":"1213-1225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<scp>Contrast\u2010Enhanced<\/scp> Ultrasound for Differentiation Between Poorly Differentiated Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma"],"prefix":"10.1002","volume":"41","author":[{"given":"Huan\u2010Ling","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasonics, Ultrasomics Artificial Intelligence X\u2010Lab, Institute of Diagnostic and Interventional Ultrasound The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou 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