{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:29:51Z","timestamp":1747150191946,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:00:00Z","timestamp":1630713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This prospective study aimed to evaluate the value of B\u2010mode lung ultrasound (LUS) for the early diagnosis of coronavirus disease 2019 (COVID\u201019) infection in nonhospitalized COVID\u201019 suspected cases in a population with a low prevalence of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From April 2020 to June 2020, in an ambulatory testing center for COVID\u201019\u2010suspected cases, 297 subjects were examined by LUS before a nasopharyngeal swab was taken for a reverse transcription polymerase chain reaction (RT\u2010PCR) test. The following LUS findings were defined as pathological ultrasound findings and were analyzed: the presence of 1) pleural effusion, 2) B\u2010lines, 3) fragmented visceral pleura, 4) consolidation, and 5) air bronchogram in the consolidation. The LUS findings were compared with the RT\u2010PCR test results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The result of the RT\u2010PCR test for severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) was positive in 11 and negative in 286 subjects, and the prevalence of COVID\u201019 infection in the study participants was 3.7%. On LUS, a pathological finding could be detected in 56\/297 (18.9%) study participants. The LUS revealed a sensitivity of 27.3%, a specificity of 81.5%, a positive predictive value of 5.4%, a negative predictive value of 96.7%, and a diagnostic accuracy of 79.9% for the identification of COVID\u201019 infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For the identification of COVID\u201019 infection, LUS is highly sensitive to the patient spectrum and to the prevalence of the disease. Due to the low diagnostic performance in nonhospitalized COVID\u201019 cases in low\u2010prevalence areas, LUS cannot be considered to be an adequate method for making a diagnosis in this group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15822","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T13:19:41Z","timestamp":1630761581000},"page":"1397-1403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Value of Lung Ultrasound to Detect the Early Pleural and Pulmonary Pathologies in Nonhospitalized <scp>COVID<\/scp>\u201019\u2010Suspected Cases in a Population With a Low Prevalence of <scp>COVID<\/scp>\u201019 Infection: A Prospective Study in 297 Subjects"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-3989","authenticated-orcid":false,"given":"Ehsan","family":"Safai Zadeh","sequence":"first","affiliation":[{"name":"Interdisciplinary Center of Ultrasound Diagnostics University Hospital Giessen and Marburg, Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina P.","family":"Huber","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center of Ultrasound Diagnostics University Hospital Giessen and Marburg, Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-6347","authenticated-orcid":false,"given":"Christoph F.","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department Allgemeine Innere Medizin (DAIM) Kliniken Hirslanden Bern, Beau Site, Salem und Permanence  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinna","family":"Trenker","sequence":"additional","affiliation":[{"name":"Haematology, Oncology and Immunology University Hospital Giessen and Marburg, Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Beutel","sequence":"additional","affiliation":[{"name":"Department of Pneumology University Hospital Giessen and Marburg, Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Wollenberg","sequence":"additional","affiliation":[{"name":"Public Health Department Marburg\u2010Biedenkopf County  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"G\u00f6rg","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center of Ultrasound Diagnostics University Hospital Giessen and Marburg, Philipps University Marburg  Marburg Germany"},{"name":"Gastroenterology, Endocrinology, Metabolism and Clinical Infectiology University Hospital Giessen and Marburg, Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2008-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.es.2020.25.3.2000045"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2020.115094"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(21)00048-7"},{"key":"e_1_2_7_6_1","unstructured":"World Health OrganizationAntigen\u2010detection in the diagnosis of SARS\u2010CoV\u20102 infection using rapid immunoassays: interim guidance. 2020.https:\/\/apps.who.int\/iris\/handle\/10665\/334253. 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